HVEM / TNFRSF14 / CD270 Molecule
HVEM / TNFRSF14 Molecule Synonym Name
HVEM / TNFRSF14 Protein Products
|Cat No||Species||Product Description|
|HV4-H82F1||Human||Biotinylated Human HVEM / TNFRSF14, Fc Tag, Avi Tag (Avitag™)|
|HVM-H5258||Human||Human HVEM / TNFRSF14 Protein, Fc Tag|
|HVM-H5283||Human||Human HVEM / TNFRSF14 Protein, Strep Tag|
|HVM-H52E9||Human||Human HVEM / TNFRSF14 Protein|
HVEM / TNFRSF14 Molecule Background
Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.
- (1) Hsu H., et al., 1997, J. Biol. Chem., 272:13471.
- (2) Mauri, D.N. et al., 1998, Immunity 8:21.
- (3) Montgomery, R.I. et al., 1996, Cell 87:427.
- (4) Cheung,T.C.et al., 2005, Proc.Natl.Acad.Sci.USA102:13218-23.