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Browse By Molecule Name --->CTLA4 / CD184 Molecule

CTLA4 / CD184 Molecule  


CTLA-4 Molecule Synonym Name

CTLA4,CD152,CELIAC3,GRD4,GSE,ICOS,IDDM12

CTLA-4 Protein Products

Cat No Species Product Description
CT4-C5227 Cynomolgus Cynomolgus CTLA-4 Protein
CT4-C5256 Cynomolgus Cynomolgus CTLA-4 Protein, Fc Tag
CT4-C82E5 Cynomolgus Biotinylated Cynomolgus CTLA-4 Protein
CT4-H5229 Human Human CTLA-4 / CD152 Protein
CT4-H5255 Human Human CTLA-4 / CD152 Protein, Fc Tag
CT4-H5284 Human Human CTLA-4 / CD152 Protein, Strep Tag
CT4-H82E4 Human Biotinylated Human CTLA-4 / CD152 Protein
CT4-H82F3 Human Biotinylated Human CTLA-4 Protein, Fc Tag
CT4-M52H5 Mouse Mouse CTLA-4 / CD152 Protein
CT4-M5256 Mouse Mouse CTLA-4 / CD152 Protein, Fc Tag

CTLA-4 Gene Products

Cat No Species Product Description
HC00139 Human Human CTLA-4 ORF Clone (NM_005214.3)

CTLA-4 Molecule Background

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

Reference

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