VCAM1 / CD106 Molecule
VCAM-1 / CD106 Molecule Synonym Name
VCAM-1 / CD106 Protein Products
|Cat No||Species||Product Description|
|VC1-H5224||Human||Human VCAM-1 / CD106 Protein|
VCAM-1 / CD106 Molecule Background
Vascular cell adhesion protein 1 (VCAM1) is also known as CD106, INCAM-100 and L1CAM, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. VCAM1 / CD106 contains 7 Ig-like C2-type (immunoglobulin-like) domains. CD106 / VCAM-1 is expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue. L1CAM / VCAM-1 is Important in cell-cell recognition and appears to function in leukocyte-endothelial cell adhesion. CD106 / VCAM1 interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1 / VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. INCAM-100 / VCAM1 binds to ECMV-D capsid proteins and acts as a receptor for this virus.
- (1) Osborn L., et al., 1992, J. Exp. Med. 176:99-107.
- (2) Zhang Z., et al., 2004, Protein Sci. 13:2819-2824.