CEACAM-1 / CD66a Molecule Synonym Name
CEACAM-1 / CD66a Protein Products
|Cat No||Species||Product Description|
|CE1-H5220||Human||Human CEACAM-1 / CD66a Protein|
CEACAM-1 / CD66a Molecule Background
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is also known as Biliary glycoprotein 1 (BGP1), CD66a, which belongs to the immunoglobulin superfamily or CEA family. CEACAM1 /CD66a contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CEACAM1 /CD66a was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 / BGP-1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
- (1) Kuroki M., et al., 1991, Biochem. Biophys. Res. Commun. 176:578-585.
- (2) Watt S.M., et al., 1994, Blood 84:200-210.
- (3) Chen R., et al., 2009, J. Proteome Res. 8:651-661.
- (4) Hoek KS., et al., 2008, Pigment Cell Melanoma Res. 21 (6): 665–76.