CD47 Molecule Synonym Name
CD47 Protein Products
|Cat No||Species||Product Description|
|CD7-C5252||Cynomolgus||Cynomolgus CD47 Protein, Fc Tag|
|CD7-H5227||Human||Human CD47 Protein|
|CD7-H5256||Human||Human CD47 Protein, Fc Tag (HPLC-verified)|
|CD7-H52A5||Human||Human CD47 Protein, mouse IgG2a Fc Tag, low endotoxin|
|CD7-H82F6||Human||Biotinylated Human CD47, Fc Tag, Avi Tag (Avitag?)|
|CD7-M5251||Mouse||Mouse CD47 Protein, Fc Tag|
|CD7-R5256||Rat||Rat CD47 Protein, Fc Tag|
|CD7-R5257||Rabbit||Rabbit CD47 Protein, Fc Tag|
|CD7-H82E9||Human||Biotinylated Human CD47 Protein, Avi Tag (Avitag?)|
|CD7-HA2E9||Human||Unconjugated Human CD47 Protein, His Tag & Avi Tag|
CD47 Molecule Background
Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
- (1) Lindberg F.P., et al., 1993, J. Cell Biol. 123:485-496.
- (2) Latour S., et al., 2001, J. Immunol. 167:2547-2554.
- (3) Piccio L., et al., 2005, Blood 105:2421-2427.