GPNMB / HGFIN Molecule
GPNMB Molecule Synonym Name
GPNMB Protein Products
|Cat No||Species||Product Description|
|GPB-H5229||Human||Human Osteoactivin / GPNMB Protein|
GPNMB Molecule Background
Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.
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- (3) Abdelmagid SM., et al., 2007, J Cell Physiol. 210 (1): 26–37.