LILRB2 / ILT4 Molecule
LILRB2 / CD85d Molecule Synonym Name
LILRB2 / CD85d Protein Products
|Cat No||Species||Product Description|
|LI2-H5220||Human||Human LILRB2 / CD85d / ILT4 Protein|
|CDD-H5259||Human||Human LILRB2 / CD85d / ILT4 Protein, Fc tag|
LILRB2 / CD85d Molecule Background
Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is also known as CD85 antigen-like family member D (CD85d), Immunoglobulin-like transcript 4 (ILT-4), Monocyte / macrophage immunoglobulin-like receptor 10 (MIR-10), which is a member of the the subfamily B class of LIR receptors. LILRB2 is receptor for class I MHC antigens. LILRB2 recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. LILRB2 competes with CD8A for binding to class I MHC antigens. LILRB2 / CD85d inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
- (1) Borges L., et al., 1997, J. Immunol. 159:5192-5196.
- (2) Fanger N.A., et al., 1998, Eur. J. Immunol. 28:3423-3434.
- (3) Shiroishi M., et al., 2003, Proc. Natl. Acad. Sci. U.S.A. 100:8856-8861.