Stathmin 1 Molecule Synonym Name
Stathmin 1 Protein Products
|Cat No||Species||Product Description|
|ST1-H5149||Human||Human Stathmin 1 / STMN1 Protein|
Stathmin 1 Molecule Background
Stathmin (STMN1), a member of the stathmin family, is also known as Leukemia-associated phosphoprotein p18, Oncoprotein 18 (Op18), Phosphoprotein p19 (pp19), Protein Pr22 and pp17, which contains one SLD (stathmin-like) domain. The function of STMN1 as an important regulatory protein of microtubule dynamics has been well-characterized. Stathmin (STMN1) interacts with two molecules of dimeric α,β-tubulin to form a tight ternary complex called the T2S complex.One mole of STMN1 binds to two moles of tubulin dimers through the stathmin-like domain (SLD).When STMN1 sequesters tubulin into the T2S complex, tubulin becomes non-polymerizable. Without tubulin polymerization, there is no microtubule assembly.STMN1 also promotes microtubule disassembly by acting directly on the microtubule ends.
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- (2) Rubin CI., et al., 2004, J Cell Biochem. 93(2):242-50.
- (3) Redeker V., et al., 2000, J. Biol. Chem. 275:6841-6849.