UBE2F / NCE2 Molecule
UBE2F Molecule Synonym Name
UBE2F Protein Products
|Cat No||Species||Product Description|
|UBF-H5148||Human||Human UBE2F Protein|
UBE2F Molecule Background
Ubiquitin-conjugating enzyme E2 F (UBE2F), a member of the ubiquitin-conjugating enzyme family and UBE2F subfamily, is also known as NEDD8-conjugating enzyme UBE2F, NEDD8 carrier protein UBE2F and NEDD8-conjugating enzyme 2 (NCE2),which can interact with UBA3 and RBX2. The acetylation of Met-1 increases affinity for DCUN1D3 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.UBE2F also can accept the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyze its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.
- (1) Huang D.T., et al., 2009, Mol. Cell 33:483-495.
- (2) Monda J.K., et al ., 2013, Structure 21:42-53.