TDGF1 / CRGF Molecule
TDGF1 / Cripto Molecule Synonym Name
TDGF1 / Cripto Protein Products
|Cat No||Species||Product Description|
|CRO-H5253||Human||Human TDGF1 / Cripto Protein, Fc Tag|
TDGF1 / Cripto Molecule Background
Teratocarcinoma-derived growth factor 1 (TDGF1) is also known as Cripto-1 growth factor (CRGF), Epidermal growth factor-like cripto protein CR1, CRIPTO, is a cell membrane which contains one EGF-like domain. TDGF1 is preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. TDGF1 interacts with the activin type-1 receptor ACVR1B. TDGF1 could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.
- (1) Bianco C., et al., 2002, Mol. Cell. Biol. 22:2586-2597.
- (2) Foley S.F., et al., 2003, Eur. J. Biochem. 270:3610-3618.
- (3) Sun C., et al., 2008, Biochem. Biophys. Res. Commun. 377:215-220.