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Human LBP / Lipopolysaccharide Protein  pdf  pdf  pdf


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Synonym

Lipopolysaccharide-binding protein,LBP

Source

Human Lipopolysaccharide-binding Protein ,His Tag, Ala 26 - Val 481 (Accession # P18428), was produced in human 293 cells (HEK293) at ACROBiosystems.

Predicted N-terminus: Ala 26

Molecular Characterization

LBP(Ala 26 - Val 481)P18428
Poly-his

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 52.8 kDa. The protein migrates as 62 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

SDS-PAGE

Human LBP / Lipopolysaccharide Protein ,His Tag (Cat. No. LBP-H52H5) SDS-PAGE gel

Human LBP / Lipopolysaccharide Protein ,His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

 

Background

Lipopolysaccharide-binding protein (LBP),a member of the BPI/LBP/Plunc superfamily, BPI/LBP family, is detected in blood serum. LBP plays a role in the innate immune response. Alao,LBP can bind to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and act as an affinity enhancer for CD14, facilitating its association with LPS. Furthermore, LBP is able to promote the release of cytokines in response to bacterial lipopolysaccharide.

References

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


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