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Human BCMA / TNFRSF17 Protein,His Tag  pdf  pdf  pdf


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BCA-H522y-100ug
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Synonym

TNFRSF17,CD269,BCM,BCMA

Source

Human BCMA, His Tag (BCA-H522y) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 54 (Accession # Q02223-1).

Predicted N-terminus: Met 1

Molecular Characterization

BCMA(Met 1 - Ala 54)Q02223-1
Poly-his

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 6.9 kDa. The protein migrates as 17 kDa under reducing (R) condition (SDS-PAGE).

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Purity

>90% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Storage

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

SDS-PAGE

Human BCMA, His Tag (Cat. No. BCA-H522y) SDS-PAGE gel

Human BCMA, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity

Human BCMA, His Tag (Cat. No. BCA-H522y) ELISA bioactivity

Immobilized Human BAFF, Fc Tag (Cat. No. BAF-H4268) at 5 μg/mL (100 μL/well) can bind Human BCMA, His Tag (Cat. No. BCA-H522y) with a linear range of 0.156-2.5 μg/mL (QC tested).

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Background

Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.

References

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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