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Human PLAU / uPA Protein  pdf  pdf  pdf

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PLU-H5229-1mg (250ug x 4)
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Human PLAU, His Tag (PLU-H5229) is expressed from human 293 cells (HEK293). It contains AA Ser 21 - Leu 431 (Accession # NP_002649.1).

Predicted N-terminus: Ser21, Ile179 & Lys156 

Molecular Characterization

PLAU(Ser 21 - Leu 431)NP_002649.1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 45 kDa. The protein migrates as four bands corresponding to the short α chain, long α chain, β chain and unprocessed full-length chain with the molecular mass of 20 kDa, 23kDa, 32 kDa and 50 kDa respectively under reducing (R) condition (SDS-PAGE) due to glycosylation and cleavage.


Less than 1.0 EU per μg by the LAL method.


>92% as determined by SDS-PAGE.


Lyophilized from 0.22 μm filtered solution in 50 mM Sodium Acetate, 100 mM NaCl, pH5.0. Normally trehalose is added as protectant before lyophilization.

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Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.


For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.


Human PLAU, His Tag (Cat. No. PLU-H5229) SDS-PAGE gel

Human PLAU, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.




Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys – Pro – Gly - Arg560 - Val561 – Val – Gly – Gly – Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction).


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