Influenza A, H7N9, H5N1, HA, Hemagglutinin, influenza (flu) virus, H1N1, H2N2, H3N2, H7N7, H1N2, H7N2, H7N3, H10N7
Influenza A Hemagglutinin (HA) Protein, A/Shanghai/2/2013(H7N9), With C-Fc Tag (HA(H7N9)-Shanghai Fc Chimera) Asp 19 - Asp 521 was produced in human 293 cells (HEK293) at ACRObiosystems.
HA(H7N9)-Shanghai Fc Chimera is fused with Fc fragment of human IgG1 at the C-terminus, and has a calculated MW of 84.5 kDa. The predicted N-terminus is Asp 19. DTT-reduced Protein migrates as 110-120 kDa due to glycosylation.
Less than 1.0 EU per μg of the HA(H7N9)-Shanghai Fc Chimera by the LAL method.
>95% as determined by SDS-PAGE.
Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
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See Certificate of Analysis for details of reconstitution instruction and specific concentration.
Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Influenza, commonly known as "the flu", is an infectious disease of birds and mammals caused by RNA viruses of the family Orthomyxoviridae, the influenza viruses. The virus is divided into three main types (Influenzavirus A, Influenzavirus B, and Influenzavirus C), which are distinguished by differences in two major internal proteins (hemagglutinin (HA) and neuraminidase (NA), which are the most important targets for the immune system. The type A viruses are the most virulent human pathogens among the three influenza types and cause the most severe disease. The serotypes that have been confirmed in humans, ordered by the number of known human pandemic deaths, are: H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, H10N7, H7N9. H7N9 is a serotype of the species Influenzavirus A (avian influenza virus or bird flu virus). H7 normally circulates amongst avian populations with some variants known to occasionally infect humans. An H7N9 virus was first reported to have infected humans in 2013 in China.
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