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Human VSIG4 Protein  pdf  pdf  pdf


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Synonym

VSIG4, CRIg, Z39IG

Source

Recombinant Human VSIG4 Protein (rh VSIG4) Arg 20 - Pro 283 (Accession # AAH10525) was produced in human 293 cells (HEK293) at ACRObiosystems.

Molecular Characterization

rh VSIG4, fused with 6×His tag at the C-terminus, has a calculated MW of 30 kDa. The predicted N-terminus is Arg 20. DTT-reduced Protein migrates as 45-48 kDa.

Endotoxin

Less than 1.0 EU per μg of the rh VSIG4 by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human VSIG4 Protein
The purity of rh VSIG4 was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Background

V-set and immunoglobulin domain-containing protein 4 (VSIG4) is also known as Protein Z39Ig, is a type I transmembrane glycoprotein. VSIG4 is a B7 family-related protein and an Ig superfamily member. VSIG4 contains two Ig-like (immunoglobulin-like) domains. VSIG4 is abundantly expressed in several fetal tissues. In adult tissues, the highest expression of VSIG4 is in lung and placenta. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. VSIG4 is a phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production.

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References

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