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Human Axl Protein  pdf  pdf  pdf


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AXL-H5226-200ug
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Synonym

AXL, UFO

Source

Recombinant Human AXL /UFO Protein (rh AXL / UFO) Ala 26 - Pro 449 (Accession # AAH32229) was produced in human 293 cells (HEK293) at ACRObiosystems.

Molecular Characterization

rh AXL / UFO, fused with polyhistidine tag at the C-terminus, has a calculated MW of 46.6 kDa. The predicted N-terminus is Ala 26. DTT-reduced Protein migrates as 60-70 kDa due to glycosylation.

Endotoxin

Less than 1.0 EU per μg of the rh AXL / UFO by the LAL method.

Purity

>92% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human AXL /UFO Protein
The purity of rh AXL / UFO was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.

Citations

 

Background

AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.

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References

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