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Human TYRO3 / Dtk Protein, Fc Tag  pdf  pdf  pdf


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Synonym

TYRO3, BYK, DTK, RSE, SKY, TIF

Source

Recombinant Human TYRO3 /DTK Protein, with C-Fc Tag (rh TYRO3 / DTK Fc Chimera) Ala 41 - Ser 428 (Accession # AAH51756) was produced in human 293 cells (HEK293) at ACRObiosystems.

Molecular Characterization

rh TYRO3 / DTK Fc Chimera, fused with Fc fragment of human IgG1 at the C-terminus, has a calculated MW of 68.2 kDa. The predicted N-terminus is Ala 41. DTT-reduced Protein migrates as 85-110 kDa due to glycosylation.

Endotoxin

Less than 1.0 EU per μg of the rh TYRO3 / DTK Fc Chimera by the LAL method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.

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Reconstitution

See Certificate of Analysis for details of reconstitution instruction and specific concentration.

Storage

Avoid repeated freeze-thaw cycles.

No activity loss was observed after storage at:
In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).

 

SDS-PAGE


Recombinant Human TYRO3 /DTK Protein, with C-Fc Tag
The purity of rh TYRO3 / DTK Fc Chimera was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
 
 

Background

Tyrosine-protein kinase receptor TYRO3 is also known as Tyrosine-protein kinase BYK, DTK, RSE, SKY, TIF, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. TYRO3 regulates many physiological processes including cell survival, migration and differentiation. TYRO3 activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 interacts (via N-terminus) with extracellular ligands TULP1 and GAS6 By similarity and also interacts with PIK3R1, this interaction increases PI3-kinase activity.

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