ADAM17 / TACE Molecule
ADAM17 / CD156b Molecule Synonym Name
ADAM17 / CD156b Protein Products
|Cat No||Species||Product Description|
|AD7-M52H1||Mouse||Mouse ADAM17 / TACE / CD156b Protein|
|AD7-R52H7||Rat||Rat ADAM17 / TACE / CD156b Protein|
ADAM17 / CD156b Molecule Background
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), a member of the ADAM protein family of disintegrins and metalloproteases, is also known as TNF-alpha convertase, TNF-alpha-converting enzyme and CD156b, which contains one disintegrin domain and one peptidase M12B domain. ADAM17 can cleave the membrane-bound precursor of TNF-alpha to its mature soluble form. ADAM17 is also responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity) and proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Furthermore, ADAM17 acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation.
- (1) Black R., et al., 1997, Nature 385 (6618): 729–33.
- (2) Moss M., et al., 1997, Nature 385 (6618): 733–6.
- (3) Schroeter E., et al., 1998, Nature 393 (6683): 382–6.