IL-17A / CTLA-8 Molecule
IL-17A / CTLA-8 Molecule Synonym Name
IL-17A / CTLA-8 Protein Products
|Cat No||Species||Product Description|
|ILA-H5118||Human||Human IL17 / IL17A Protein, Tag Free|
|CT8-M5240||Mouse||Mouse IL-17A / CTLA-8 Protein|
IL-17A / CTLA-8 Molecule Background
Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
- (1) Yao Z., et al.,1995, J. Immunol. 155:5483-5486.
- (2) Gerhardt S., et al., 2009, J. Mol. Biol. 394:905-921.