PSME3 Molecule Synonym Name
PSME3 Protein Products
|Cat No||Species||Product Description|
|PS3-H5142||Human||Human PSME3 / PA28g Protein|
PSME3 Molecule Background
Proteasome activator complex subunit 3 (PSME3),a member of the PA28 family, is also known as 11S regulator complex subunit gamma (REG-gamma), activator of multicatalytic protease subunit 3 and proteasome activator 28 subunit gamma (PA28gamma). PSME3 activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. PSME3 can also facilitate the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. Furthermore,PSME3 may also be involved in cell cycle regulation.
- (1) Miki Y., et al., 1994, Science 266:66-71.
- (2) Realini C., et al., 1997,J. Biol. Chem. 272:25483-25492.
- (3) Zhang Z., et al., 2008, EMBO J. 27:852-864.