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IGFBP-4 Molecule  


IGFBP-4 Molecule Synonym Name

IGFBP4,IBP-4

IGFBP-4 Protein Products

Cat No Species Product Description
IG4-H52E4HumanHuman IGFBP-4 Protein

IGFBP-4 Molecule Background

Insulin-like growth factor-binding protein 4 (IGFBP-4) is also known as IGF-binding protein 4, which contains an IGFBP domain and a thyroglobulin type-I domain. IGFBP-4 binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. IGFBP-4 is secreted by all colon cancer cells.

Reference

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