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IL23A & IL12B Molecule  

IL23A & IL12B Molecule Synonym Name

IL-23 alpha & IL-12 beta

IL23A & IL12B Protein Products

Cat No Species Product Description
ILB-H52W5 Human Human IL-23 alpha & IL-12 beta Heterodimer Protein
ILB-HM52W6 Human & Mouse Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein
ILB-M52W7 Mouse Mouse IL-23 alpha & IL-12 beta Heterodimer Protein
ILB-H82W6 Human Biotinylated Human IL-23 alpha & IL-12 beta, Avi Tag (Avitag)

IL23A & IL12B Molecule Background

Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.