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Your Position: Home > Reporter Cell Lines

Reporter Cell Lines

Reporter Cell Lines
Background
Application scenario
Product list
Background
Antibody drugs have undergone decades of research and development after the world’s first monoclonal antibody drug, muromonab-CD3. Antibody therapies have become the fastest growing biological drug field and have revolutionized the treatment landscape for wide array of diseases, especially in cancer. Presently, over 100 antibody drugs have been commercialized across the globe, playing an important role in clinical treatment in vitro diagnostics, research, and many other fields.
Cellular-level evaluation is a key indicator for drug efficacy in vitro and is widely used throughout the drug development process. However, when using conventional cells, many traditional analytical methods have disadvantages including low sensitivity, poor reproducibility, complicated operations, and low throughput. This is further exacerbated by the batch-to-batch variation in primary cells, and results in a significant bottleneck during antibody drug development.
Instead of using traditional cells, our reporter cell lines are constructed using genetic engineering to help standardize and minimize the batch-to-batch variation during cell passaging. Reporter cell lines are based on the drug mechanism of action (MOA) and helps various studies, including:
Establish the correlation between the target transduction signal and the reporter gene expression in the cell.
Monitor the target signaling pathway by detecting the expression of the reporter gene transduction.
To meet the needs of new drug development, ACROBiosystems uses a luciferase reporter gene system to establish a reporter gene cell platform and continues to develop a series of high-quality reporter gene cell line products. The series of cell line products are verified for functionality and stability and designed to be applied to signal transduction function research, early drug discovery and screening, and CMC quality control release!

Application scenario
ADCC/ADCP Functional Assays
ADCC/ADCP Functional Assays
Target & Transduction research
Target & Transduction research
Cross-linking drug evaluation
Cross-linking drug evaluation
Immune checkpoint drug research
Immune checkpoint drug research
Click here to learn more about customizing cell lines!
Product advantage

Designed for the verification of drug mechanism-of-actions.

Strong response signal ensures high sensitivity.

Verified stable passage for more than 20 generations.

Supporting product supply to achieve a one-stop service.

Large detection window that is suitable for screening of different drug effects.

Regulatory document support.

Product list

  • ADCC/ADCP functional verification

  • Target & Transduction research

  • Cross-linking drug evaluation

  • Immune checkpoint drug research

ApplicationMoleculeCat. No.Product description
ADCPFc gamma RI / CD64SCJUR-STF072Human CD64 (Luc) Jurkat Reporter Cell Development Service
Fc gamma RIIA / CD32aSCJUR-STF069Human CD32a (131H) (Luc) Jurkat Reporter Cell Development Service
Fc gamma RIIA / CD32aSCJUR-STF070Human CD32a (131R) (Luc) Jurkat Reporter Cell Development Service
Fc gamma RIIB / CD32bSCJUR-STF071Human CD32b (Luc) Jurkat Reporter Cell Development Service
ADCCFc gamma RIIIA / CD16aSCJUR-STF067Human CD16a (158V) (Luc) Jurkat Reporter Cell Development Service
Fc gamma RIIIA / CD16aSCJUR-STF068Human CD16a (158F) (Luc) Jurkat Reporter Cell Development Service
MoleculeCat. No.Reporter Cell Product Description
MoleculeCat. No.Stable Cell Product Description
MoleculeCat. No.Product Description
MoleculeCat. No.Product Description
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