Nectin-3 / CD113 Molecule
Nectin-3 / CD113 Molecule Synonym Name
Nectin-3 / CD113 Protein Products
|Cat No||Species||Product Description|
|PV3-H5255||Human||Human Nectin-3 / CD113 Protein, Fc Tag|
|PV3-H52E4||Human||Human Nectin-3 / CD113 Protein|
Nectin-3 / CD113 Molecule Background
Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.
- (1) Mueller S., et al., 2003, J. Biol. Chem. 278:31251-31260.
- (2) Yu X., et al., 2009, Nat. Immunol. 10:48-57.