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Browse By Molecule Name --->Nectin-3 / CD113 Molecule

Nectin-3 / CD113 Molecule  

Nectin-3 / CD113 Molecule Synonym Name


Nectin-3 / CD113 Protein Products

Cat No Species Product Description
PV3-H5255 Human Human Nectin-3 / CD113 Protein, Fc Tag
PV3-H52E4 Human Human Nectin-3 / CD113 Protein
PV3-H82F3 Human Biotinylated Human Nectin-3 / CD113 Protein, Fc Tag, Avi Tag (Avitag™)

Nectin-3 / CD113 Molecule Background

Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.