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Bulk Recombinant Proteins --->Fc Receptor Proteins

Fc Receptor Proteins  


General Description

The efficacy of a therapeutic antibody not only depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors. The binding affinity of the Fc fragment towards FcRn (FCGRT&B2M) would predict the antibody’s half life, while that between the Fc fragment and FCGRIIIA (CD16a) would influence the antibody’s ability to elicit ADCC (antibody dependent cell mediated cytotoxicity). Hence, screening for desired binding affinity to these Fc receptors is an essential component in the development of a therapeutic mAb (monoclonal antibody).

ACROBiosystems offers a comprehensive collection of recombinant Fc receptor proteins, including their common variants, to help expedite your mAb development.

Product List

Molecule Catalog No. Species Product Name Size List Price
FcRn / FCGRT & B2M FCM-H5286 Human FcRn / FCGRT & B2M Heterodimer Protein 50ug/1mg $350/$2,400
FCM-H8286 Human Biotinylated FcRn / FCGRT & B2M, ultra sensitivity (primary amine labeling) 25ug/200ug $290/$1,250
FCM-H82W4 Human Biotinylated FcRn / FCGRT & B2M, Avi Tag (Avitag™) 25ug/200ug $350/$1,380
FCM-M52W2 Mouse FcRn / FCGRT & B2M Heterodimer Protein 50ug/1mg $315/$2,200
FCM-M82W6 Mouse Biotinylated FcRn / FCGRT & B2M, Avi Tag (Avitag™) 25ug/200ug $350/$1,380
FCM-R5287 Rat FcRn / FCGRT & B2M Heterodimer Protein 50ug/1mg $315/$2,200
FCM-R82W7 Rat Biotinylated FcRn / FCGRT & B2M, Avi Tag (Avitag™) 25ug/200ug $350/$1,380
FCM-C5284 Cynomolgus FcRn / FCGRT & B2M Heterodimer Protein 50ug/1mg $315/$2,200
FCM-C82W5 Cynomolgus Biotinylated FcRn / FCGRT & B2M, Avi Tag (Avitag™) 25ug/200ug $350/$1,380
FCM-P5280 Porcine FcRn / FCGRT & B2M Heterodimer Protein 50ug/1mg $315/$2,200
Fc gamma RIIIA / CD16a CD8-H52H4 Human FCGR3A / CD16a (V176) Protein 100ug/1mg $260/$1,600
CDA-H5220 Human FCGR3A / CD16a (F176) Protein 100ug/1mg $350/$1,980
CDA-H82E8 Human Biotinylated Fc gamma RIIIA / CD16a (F176), Avi Tag (Avitag™) 25ug/200ug $350/$1,380
CDA-H82E9 Human Biotinylated Fc gamma RIIIA / CD16a (V176), Avi Tag (Avitag™) 25ug/200ug $350/$1,380
CDA-M52H8 Mouse FCGR3A / CD16a Protein 100ug/1mg $280/$1,700
Fc gamma RIIIB / CD16b CDB-H5222 Human Human Fc gamma RIIIB / CD16b (NA2) Protein 100ug/1mg $260/$1,600
CDB-H82E4 Human Biotinylated Human Fc gamma RIIIB / CD16b (NA1), His Tag & Avi Tag (Avitag™) 25ug/200ug $350/$1,380
CDB-H5227 Human Human Fc gamma RIIIB / CD16b (NA1) Protein, His tag 100ug/1mg $410/$2,700
Fc gamma RIIA / CD32a CD1-H5223 Human FcGR2A / CD32a (H167) Protein 100ug/1mg $260/$1,600
CDA-H5221 Human Fc gamma RIIA / CD32a (R167) Protein 100ug/1mg $260/$1,600
CDA-H82E6 Human Biotinylated Fc gamma RIIA / CD32a (H167), Avi Tag (Avitag™) 25ug/200ug $350/$1,380
CDA-H82E7 Human Biotinylated Fc gamma RIIA / CD32a (R167), Avi Tag (Avitag™) 25ug/200ug $350/$1,380
Fc gamma RIIB / CD32b CDB-H5228 Human Fc gamma RIIB / CD32b Protein 100ug/1mg $260/$1,600
CDB-M82E8 Mouse Biotinylated Fc gamma RIIB / CD32b, Avi Tag (Avitag™) 25ug/200ug $350/$1,380
Fc gamma RI / CD64 FCA-H52H2 Human Fc gamma RI / CD64 Protein 100ug/1mg $280/$1,950
CD4-M5227 Mouse Fc gamma RI / CD64 Protein 100ug/1mg $250/$1,700
CD23 CD3-H82Q5 Human Biotinylated Human CD23 / Fc epsilon RII Protein, His Tag & Avi Tag (Avitag™) 25ug/200ug $350/$1,380

Why Choose Us

Authentic Human Cell-Expressed Proteins

High Quality Materials

The consistency in purity and bioactivity is essential in the successful production of biotinylated proteins. All our proteins are evaluated by a variety of methods throughout the production process to ensure all relevant requirements are met.

FcRn Purity
  1. Purity greater than 95% by SDS-PAGE and SEC-HPLC
  2. Bioactivity validated in functional ELISA
  3. Endotoxin less than 1EU/µg by the LAL method
The purity of human FcRn (FCM-H5286) was greater than 95% as determined in a HPLC analysis.

Biotinylated Proteins Available

The use of biotin labeling can make your assay development much easier. We offer a variety of ready-to-use biotinylated Fc receptors. These proteins are produced using our in-house developed labeling techniques, which confers high bioactivity and minimal batch-to-batch variation.

Biotinylated FcRnBiotinylated Human FcRn / FCGRT & B2M, Avi Tag (Avitag™) (Cat.# FCM-H82W4) coupled to SA coated sensor chip can bind Herceptin with an affinity constant of 2.24 μM as determined in a SPR assay (Biacore 2000). The data is generally provided by Biaffin GmbH &Co KG, Germany

Binding Activity Validated

The binding activity of our Fc receptors have been thoroughly evaluated by both SPR and ELISA analyses prior to launch.

FcRn Immobilized Human FcRn / FCGRT & B2M Heterodimer Protein(Cat. No. FCM-H5286) on CM5 Chip, can bind Herceptin with an affinity constant of 0.427 μM as determined in SPR assay (Biacore 8K) ( Routinely tested).