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Your Position: Home > RSA

RSA

Brief Information

Name:Leukocyte-associated immunoglobulin-like receptor 1
Target Synonym:Immunoglobulin Heavy Chain Variable Region,HLAIR1,LAIR1,Leukocyte Associated Immunoglobulin Like Receptor 1,CD305 Antigen,hLAIR1,CD305,Leukocyte-Associated Ig-Like Receptor 1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 2 Clinical
ACRO Quality

Synonym Name

RSA,ALB,Serum albumin

Background

serum albumin (SA) is also known as ALB, which is the main protein of plasma and has a good binding capacity for water,Ca2+,Na+,K+,fatty acids,hormones, bilirubin and drugs.The main function of SA is the regulation of the colloidal osmotic pressure of blood. As Major zinc transporter in plasma, SA typically binds about 80% of all plasma zinc. A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood. Defects in serum albumin can cause familial dysalbuminemic hyperthyroxinemia which is a form of euthyroid hyperthyroxinemia that is due to increased affinity of serum albumin for T4. It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
NGM-438 NGM-438 Phase 1 Clinical Merck & Co Inc, Ngm Biopharmaceuticals Inc Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Mesothelioma; Cholangiocarcinoma; Breast Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
NC-410 NC-410 Phase 2 Clinical Nextcure Inc Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Colorectal Neoplasms Details
NGM-438 NGM-438 Phase 1 Clinical Merck & Co Inc, Ngm Biopharmaceuticals Inc Ovarian Neoplasms; Solid tumours; Carcinoma, Renal Cell; Squamous Cell Carcinoma of Head and Neck; Esophageal Neoplasms; Stomach Neoplasms; Carcinoma, Transitional Cell; Pancreatic Neoplasms; Mesothelioma; Cholangiocarcinoma; Breast Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms; Melanoma; Carcinoma, Non-Small-Cell Lung; Uterine Cervical Neoplasms Details
NC-410 NC-410 Phase 2 Clinical Nextcure Inc Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Colorectal Neoplasms Details

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