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E-Selectin Molecule Information

Name:Selectin E
Target Synonym:Leukocyte-endothelial cell adhesion molecule 2;SELE;E-selectin;LECAM2;ELAM1;CD_antigen=CD62E;ELAM-1;Endothelial leukocyte adhesion molecule 1;CD62 antigen-like family member E
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:11
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
CDE-H5250 Human Human E-Selectin / CD62E Protein, Fc Tag
CDE-H5222 Human Human E-Selectin / CD62E Protein, His Tag

E-Selectin Molecule Synonym Name


E-Selectin Molecule Background

E-Selectin is also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2),  a member of the Selectin family, is a 107-115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1¦Â and TNF¦Á. E selectin has a cassette structure: an N-terminal, C-type lectin domain, an EGF (epidermal-growth-factor)-like domain, 6 Sushi domain (SCR repeat) units, a transmembrane domain (TM) and an intracellular cytoplasmic tail (cyto). During inflammation, E-selectin plays an important part in recruiting leukocytes to the site of injury. The local release of cytokines IL-1 and TNF-¦Á by damaged cells induces the over-expression of E-selectin on endothelial cells of nearby blood vessels. E-selectin mediates the adhesion of tumor cells to endothelial cells, by binding to E-selectin ligands expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, natural killer cells or cancer cells. Furthermore, a number of studies have reported that levels of E-Selectin may be elevated in subjects with a variety of pathological conditions.

E-Selectin References

E-Selectin Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
GI-270384X GI-270384X; GI-270384 Phase Ⅱ GlaxoSmithKline Inflammatory bowel disease Details
Bimosiamose TBC-1269 Phase Ⅱ Encysive, Revotar Plaque psoriasis, Atopic dermatitis, Chronic obstructive pulmonary disease (COPD), Asthma Details
Uproleselan GMI-1271 Phase Ⅲ GlycoMimetics Pharmaceutical Deep vein thrombosis (DVT), Stem cell mobilization, Multiple myeloma (MM), Acute myeloid Leukemia (AML) Details
E-selectin targeting humanized antibody (LifeArc) Phase Ⅰ LifeArc Sepsis, Adult respiratory distress syndrome (ADRS) Details
CY-1787 Phase Ⅰ Epimmune Inc., Sumitomo Dainippon Systemic inflammatory response syndrome (SIRS), Septic shock, Allergic rhinitis (AR) Details
CY-1503 CY-1503 Phase Ⅲ Epimmune Inc., Sumitomo Dainippon Reperfusion injury, Respiratory-tract disorders Details
GMI-1687 GMI-1687 Preclinical GlycoMimetics Pharmaceutical Acute myeloid Leukemia (AML) Details
Rivipansel Sodium GM-1070; GMI-1070; PF-06460031-02; PF-06460031 (free base); PF-6460031 ,GMI1070,PF0646003102 Phase Ⅲ GlycoMimetics Pharmaceutical, Pfizer Sickle cell vaso-occlusive crisis Details
Recombinant E-selectin (Novavax/NINDS) Phase Ⅱ National Institute of Neurological Disorders and Stroke, Novavax Stroke, Myocardial infarction (MI) Details
CDP-850 CDP-850 Phase Ⅱ Celltech Psoriasis Details
GMI-1359 GMI-1359 Phase Ⅰ GlycoMimetics Pharmaceutical Solid tumours Details
Monoclonal antibody EP-5C7  (PDL BioPharma) EP-5C7 Phase Ⅰ PDL BioPharma Stroke, Autoimmune diseases, Psoriasis, Shock, Asthma Details

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