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E-Selectin

Brief Information

Name:Selectin E
Target Synonym:Leukocyte Endothelial Cell Adhesion Molecule 2,LECAM2,ELAM1,Endothelial leukocyte adhesion molecule 1,ELAM-1,SELE,Selectin E,CD62 Antigen-Like Family Member E,Endothelial Adhesion Molecule 1,Leukocyte-Endothelial Cell Adhesion Molecule 2,CD62E Antigen,CD6
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 3 Clinical

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Cat. No. Species Product Description Structure Purity Feature
CDE-H5250 Human Human E-Selectin / CD62E Protein, Fc Tag
CDE-H5250-structure
CDE-H5250-sds
CDE-H5222 Human Human E-Selectin / CD62E Protein, His Tag
CDE-H5222-structure
CDE-H5222-sds

Synonym Name

SELE,RP1-117P20.2,CD62E,ELAM1,ESEL,LECAM2,E-Selectin

Background

E-Selectin is also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), a member of the Selectin family, is a 107-115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1β and TNFα. E selectin has a cassette structure: an N-terminal, C-type lectin domain, an EGF (epidermal-growth-factor)-like domain, 6 Sushi domain (SCR repeat) units, a transmembrane domain (TM) and an intracellular cytoplasmic tail (cyto). During inflammation, E-selectin plays an important part in recruiting leukocytes to the site of injury. The local release of cytokines IL-1 and TNF-α by damaged cells induces the over-expression of E-selectin on endothelial cells of nearby blood vessels. E-selectin mediates the adhesion of tumor cells to endothelial cells, by binding to E-selectin ligands expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, natural killer cells or cancer cells. Furthermore, a number of studies have reported that levels of E-Selectin may be elevated in subjects with a variety of pathological conditions.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
E-selectin targeting humanized antibody (LifeArc) Phase 1 Clinical Lifearc Sepsis; Respiratory Distress Syndrome, Adult Details
GMI-1359 GMI-1359 Phase 1 Clinical Glycomimetics Pharmaceutical Breast Neoplasms; Metastatic breast cancer Details
Uproleselan GMI-1271; APL-106 Phase 3 Clinical Glycomimetics Pharmaceutical Multiple Myeloma; Leukemia, Myeloid, Acute; Venous Thrombosis Details

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