Name:Sodium channel protein type VIII alpha subunit Target Synonym:Sodium channel protein type 8 subunit alpha,Sodium channel protein type VIII subunit alpha,MED,SCN8A,Sodium Voltage-Gated Channel Alpha Subunit 8,Voltage-Gated Sodium Channel Subunit Alpha Nav1.6,Sodium Channel, Voltage Gated, Type VIII, Alpha Polypeptide
Number of Launched Drugs:2 Number of Drugs in Clinical Trials:2 Lastest Research Phase:Approved
Synonym Name
MED1
Background
MED1 (Mediator Subunit1) was identified as a key transcriptional coactivator for ERα during both normal mammary gland development and breast tumorigenesis. MED1 takes a key role for the crosstalk between HER2 and ERα pathway. MED1 regulates ERα-mediated transcription and leads to resistance of breast cancer cells to anti-estrogen therapies.
Clinical and Translational Updates
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