MED1 Protein - ACROBiosystems

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MED1

Brief Information

Name:Sodium channel protein type VIII alpha subunit
Target Synonym:Sodium channel protein type 8 subunit alpha,Sodium channel protein type VIII subunit alpha,MED,SCN8A,Sodium Voltage-Gated Channel Alpha Subunit 8,Voltage-Gated Sodium Channel Subunit Alpha Nav1.6,Sodium Channel, Voltage Gated, Type VIII, Alpha Polypeptide

Number of Launched Drugs:2
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Approved

Synonym Name

MED1

Background

MED1 (Mediator Subunit1) was identified as a key transcriptional coactivator for ERα during both normal mammary gland development and breast tumorigenesis. MED1 takes a key role for the crosstalk between HER2 and ERα pathway. MED1 regulates ERα-mediated transcription and leads to resistance of breast cancer cells to anti-estrogen therapies.

Clinical and Translational Updates

Public Drug Information

Name	Research Code	Research Phase	Company	First Brand Name	First Approved Country	First Indication	First Approved Company	First Approved Date	Indications	Clinical Trials
Pirmenol Hydrochloride	CI-845	Approved	Pfizer Pharmaceuticals Ltd (China), Sumitomo Dainippon	Pimavar, Pimenol	Japan	Arrhythmias, Cardiac	null	1994-01-01	Arrhythmias, Cardiac	Details
Pilsicainide Hydrochloride	DU-6552; SUN-1165	Approved	Daiichi Sankyo Co Ltd	Sunrythm	Japan	Tachycardia	Daiichi Sankyo Co Ltd	1991-03-29	Tachycardia	Details

Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
PRAX-330		Phase 1 Clinical		Epilepsy	Details
PRAX-562	PRAX-562		Praxis Precision Medicines		Details
XEN-901	NBI-921352; XEN-901	Phase 2 Clinical	Xenon Pharma	Brain Diseases; Epilepsy	Details