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Your Position: Home > CD36

CD36

Brief Information

Name:Platelet glycoprotein 4
Target Synonym:CD36 Molecule,GP3B,GPIV,FAT,GP4,CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor),CD36 Molecule (Thrombospondin Receptor),Leukocyte Differentiation Antigen CD36,Platelet Glycoprotein IV,Platelet Glycoprotein 4,Fatty Acid Translocase,Glycoprotein IIIb,SCARB3,GPIIIB,PAS IV,Scavenger Receptor Class B, Member 3,Platelet Collagen Receptor,Thrombospondin Receptor,Cluster Determinant 36,PAS-4 Protein,CD36 Antigen,BDPLT10,CHDS7,PASIV,PAS-4
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

Licensing

Project Name Modality Therapeutic Area Indications Stage Right Available
Antagonizing TSP1/CD36 Polypeptide Blocking the activation of TGF-β1 Fusion/Recombination protein Respiratory disease IPF,PF-ILD IND Global  (except China)

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Cat. No. Species Product Description Structure Purity Feature
CD6-H5258 Human Human CD36 / SR-B3 Protein, Fc Tag
CD6-H5258-structure
CD6-H5258-sds
CD6-H82F4 Human Biotinylated Human CD36 / SR-B3 Protein, Fc,Avitag™
CD6-H82F4-structure
CD6-H82F4-sds
CD6-M5254 Mouse Mouse CD36 / SR-B3 Protein, Fc Tag
CD6-M5254-structure
CD6-M5254-sds
CD6-C52H6 Canine Canine CD36 / SR-B3 Protein, His Tag
CD6-C52H6-structure
CD6-C52H6-sds
CD6-C52H8 Cynomolgus Cynomolgus CD36 / SR-B3 Protein, His Tag
CD6-C52H8-structure
CD6-C52H8-sds
CD6-M52H3 Mouse Mouse CD36 / SR-B3 Protein, His Tag
CD6-M52H3-structure
CD6-M52H3-sds
CD6-H82E9 Human Biotinylated Human CD36 / SR-B3 Protein, His,Avitag™
CD6-H82E9-structure
CD6-H82E9-sds
CD6-H5221 Human Human CD36 / SR-B3 Protein, His Tag (MALS verified)
CD6-H5221-structure
CD6-H5221-sds
ACRO Quality

Part of Bioactivity data

CD6-H82F4-ELISA
CD36 ELISA

Immobilized Mouse/IgG1,CD36 Antibody at 1 μg/mL (100 μL/well) can bind Biotinylated Human CD36 Protein, Fc,Avitag (Cat. No. CD6-H82F4) with a linear range of 1-31 ng/mL (QC tested).

Protocol
CD6-H5221-MALS-HPLC
CD36 MALS images

The purity of Human CD36, His Tag (Cat. No. CD6-H5221) is more than 90% and the molecular weight of this protein is around 58-78 kDa verified by SEC-MALS.

Synonym Name

CD36,SCARB3,BDPLT10,CHDS7,FAT,GP3B,GP4,GPIV,PASIV,Platelet Glycoprotein 4,glycoprotein IV,gpIV,glycoprotein IIIb,gpIIIb

Background

CD36 (Cluster of Differentiation 36) is also known as platelet membrane glycoprotein IV (GPIV), fatty acid translocase (FAT), thrombospondin receptor, collagen receptor, and scavenger receptor class B, member 3 (SRB3), is a member of the class B scavenger receptor family of cell surface proteins. The human CD36 gene encodes a single chain 472 amino acid residue protein containing both an N- and a C-terminal cytoplasmic tail and an extracellular loop.CD36 is found on platelets, erythrocytes, monocytes, differentiated adipocytes, mammary epithelial cells, spleen cells and some skin microdermal endothelial cells. CD36 is a multiligand pattern recognition receptor that interacts with a large number of structurally dissimilar ligands, including long chain fatty acid (LCFA), advanced glycation end products (AGE), thrombospondin-1, oxidized low-density lipoproteins (oxLDLs), high density lipoprotein (HDL), phosphatidylserine, apoptotic cells, beta-amyloid fibrils (fAβ), collagens I and IV, and Plasmodium falciparum infected erythrocytes. CD36 is required for the anti-angiogenic effects of thrombospondin1 In the corneal neovascularization assay. On binding a ligand the protein and ligand are internalized. This internalization is independent of macropinocytosis and occurs by an actin dependent mechanism requiring the activation Src-family kinases, JNK and Rho-family GTPases. CD36 ligands have also been shown to promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

Clinical and Translational Updates

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