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Your Position: Home > CD36

CD36

Brief Information

Name:Platelet glycoprotein 4
Target Synonym:CD36 Molecule,GP3B,GPIV,FAT,GP4,CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor),CD36 Molecule (Thrombospondin Receptor),Leukocyte Differentiation Antigen CD36,Platelet Glycoprotein IV,Platelet Glycoprotein 4,Fatty Acid Translocase,Glycoprotein IIIb,SCARB3,GPIIIB,PAS IV,Scavenger Receptor Class B, Member 3,Platelet Collagen Receptor,Thrombospondin Receptor,Cluster Determinant 36,PAS-4 Protein,CD36 Antigen,BDPLT10,CHDS7,PASIV,PAS-4
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

Licensing

Project item Indications Research phase Cooperation demands
BPS21001 Progressive Fibrosis Interstitial Lung Disease (PF-ILD), Solid Tumor. IND Approval in China Out-licensing outside the Great China

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Part of Bioactivity data

CD6-H5221-ELISA
Human CD36, His TagHuman CD36, His Tag (Cat. No. CD6-H5221) ELISA bioactivity

Immobilized Mouse/IgG1,CD36 Antibody at 1 μg/mL (100 μL/well) can bind Human CD36, His Tag (Cat. No. CD6-H5221) with a linear range of 1-16 ng/mL (QC tested).

CD6-H5221-MALS-HPLC
Human CD36, His Tag (Cat. No. ) MALS images

The purity of Human CD36, His Tag (Cat. No. CD6-H5221) is more than 90% and the molecular weight of this protein is around 58-78 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human CD36, His TagHuman CD36, His Tag (Cat. No. CD6-H5221) ELISA bioactivity

Immobilized Mouse/IgG1,CD36 Antibody at 1 μg/mL (100 μL/well) can bind Human CD36, His Tag (Cat. No. CD6-H5221) with a linear range of 1-16 ng/mL (QC tested).

Synonym Name

CD36,SCARB3,BDPLT10,CHDS7,FAT,GP3B,GP4,GPIV,PASIV,Platelet Glycoprotein 4,glycoprotein IV,gpIV,glycoprotein IIIb,gpIIIb

Background

CD36 (Cluster of Differentiation 36) is also known as platelet membrane glycoprotein IV (GPIV), fatty acid translocase (FAT), thrombospondin receptor, collagen receptor, and scavenger receptor class B, member 3 (SRB3), is a member of the class B scavenger receptor family of cell surface proteins. The human CD36 gene encodes a single chain 472 amino acid residue protein containing both an N- and a C-terminal cytoplasmic tail and an extracellular loop.CD36 is found on platelets, erythrocytes, monocytes, differentiated adipocytes, mammary epithelial cells, spleen cells and some skin microdermal endothelial cells. CD36 is a multiligand pattern recognition receptor that interacts with a large number of structurally dissimilar ligands, including long chain fatty acid (LCFA), advanced glycation end products (AGE), thrombospondin-1, oxidized low-density lipoproteins (oxLDLs), high density lipoprotein (HDL), phosphatidylserine, apoptotic cells, beta-amyloid fibrils (fAβ), collagens I and IV, and Plasmodium falciparum infected erythrocytes. CD36 is required for the anti-angiogenic effects of thrombospondin1 In the corneal neovascularization assay. On binding a ligand the protein and ligand are internalized. This internalization is independent of macropinocytosis and occurs by an actin dependent mechanism requiring the activation Src-family kinases, JNK and Rho-family GTPases. CD36 ligands have also been shown to promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

Clinical and Translational Updates

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