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CD36

CD36 Molecule Information

Name:Platelet glycoprotein 4
Target Synonym:CD36 Molecule,GP3B,GPIV,FAT,GP4,CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor),CD36 Molecule (Thrombospondin Receptor),Leukocyte Differentiation Antigen CD36,Platelet Glycoprotein IV,Platelet Glycoprotein 4,Fatty Acid Translocase,Glycopr
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

CD36 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
CD6-M52H3 Mouse Mouse CD36 / SR-B3 Protein, His Tag
CD6-M52H3-structure
CD6-M52H3-sds
CD6-H82E9 Human Biotinylated Human CD36 / SR-B3 Protein, His,Avitag™
CD6-H82E9-structure
CD6-H82E9-sds
CD6-H82E9-elisa_1
CD6-H5221 Human Human CD36 / SR-B3 Protein, His Tag
CD6-H5221-structure
CD6-H5221-sds
CD6-H5221-elisa_2

CD36 Part of Bioactivity data

CD6-H5221-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human CD36, His Tag (Cat. No. CD6-H5221) immobilized on CM5 Chip can bind Human Thrombospondin-2, His Tag (Cat. No. TH2-H52H5) with an affinity constant of 21 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

CD6-H82E9-ELISA
Biotinylated Human CD36, His,AvitagBiotinylated Human CD36, His,Avitag (Cat. No. CD6-H82E9) ELISA bioactivity

Immobilized Human R-Spondin 1, His Tag (Cat. No. RS1-H4221) at 5 μg/mL (100 μL/well) can bind Biotinylated Human CD36, His,Avitag (Cat. No. CD6-H82E9) with a linear range of 0.313-1.25 μg/mL (QC tested).

CD36 Molecule Synonym Name

CD36,SCARB3,BDPLT10,CHDS7,FAT,GP3B,GP4,GPIV,PASIV,Platelet Glycoprotein 4,glycoprotein IV,gpIV,glycoprotein IIIb,gpIIIb

CD36 Molecule Background

CD36 (Cluster of Differentiation 36) is also known as platelet membrane glycoprotein IV (GPIV), fatty acid translocase (FAT), thrombospondin receptor, collagen receptor, and scavenger receptor class B, member 3 (SRB3), is a member of the class B scavenger receptor family of cell surface proteins. The human CD36 gene encodes a single chain 472 amino acid residue protein containing both an N- and a C-terminal cytoplasmic tail and an extracellular loop.CD36 is found on platelets, erythrocytes, monocytes, differentiated adipocytes, mammary epithelial cells, spleen cells and some skin microdermal endothelial cells. CD36 is a multiligand pattern recognition receptor that interacts with a large number of structurally dissimilar ligands, including long chain fatty acid (LCFA), advanced glycation end products (AGE), thrombospondin-1, oxidized low-density lipoproteins (oxLDLs), high density lipoprotein (HDL), phosphatidylserine, apoptotic cells, beta-amyloid fibrils (fAβ), collagens I and IV, and Plasmodium falciparum infected erythrocytes. CD36 is required for the anti-angiogenic effects of thrombospondin1 In the corneal neovascularization assay. On binding a ligand the protein and ligand are internalized. This internalization is independent of macropinocytosis and occurs by an actin dependent mechanism requiring the activation Src-family kinases, JNK and Rho-family GTPases. CD36 ligands have also been shown to promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

CD36 References

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