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Your Position: Home > Other Recombinant Proteins > Stathmin 1 > Human STMN1 /Stathmin Protein

Human Stathmin 1 / STMN1 Protein

  • Synonym
    STMN1,Stathmin,C1orf215,LAP18,OP18
  • Source
    Human Stathmin 1, His Tag (ST1-H5149) is expressed from E.coli cells. It contains AA Ala 2 - Asp 149 (Accession # NP_981946).
    Predicted N-terminus: Met
  • Molecular Characterization
    Stathmin 1(Ala 2 - Asp 149) NP_981946

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 18.1 kDa. The protein migrates as 17-20 kDa under reducing (R) condition (SDS-PAGE).

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >92% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human Stathmin 1, His Tag (Cat. No. ST1-H5149) SDS-PAGE gel

Human Stathmin 1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.

  • Background
    Stathmin (STMN1), a member of the stathmin family, is also known as Leukemia-associated phosphoprotein p18, Oncoprotein 18 (Op18), Phosphoprotein p19 (pp19), Protein Pr22 and pp17, which contains one SLD (stathmin-like) domain. The function of STMN1 as an important regulatory protein of microtubule dynamics has been well-characterized. Stathmin (STMN1) interacts with two molecules of dimeric α,β-tubulin to form a tight ternary complex called the T2S complex.One mole of STMN1 binds to two moles of tubulin dimers through the stathmin-like domain (SLD).When STMN1 sequesters tubulin into the T2S complex, tubulin becomes non-polymerizable. Without tubulin polymerization, there is no microtubule assembly.STMN1 also promotes microtubule disassembly by acting directly on the microtubule ends.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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