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Your Position: Home > All Other Proteins > IGF-I R > Rat IGF-I R / CD221 Protein

Rat IGF-I R / CD221 Protein

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  • Synonym
    IGF1R,CD221,IGFR,JTK13,MGC142170,MGC142172,MGC18216
  • Source
    Rat IGF-I R (IGR-R5224) is expressed from human 293 cells (HEK293). It contains AA Glu 31 - His 936 (Accession # P24062-1).
    Predicted N-terminus: Glu 31, Asp 742
  • Molecular Characterization
    IGF-I R(Glu 31 - His 936) P24062-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 105.5 kDa, 81.3 kDa, 24.2 kDa.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;

    2. -70°C for 3 months under sterile conditions after reconstitution.

  • Background
    The Insulin-like Growth Factor 1 Receptor (IGF1) is also known as CD221, JTK13. and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF1R is make up of two alpha subunits and two beta subunits ,the Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain.The α chains are located extracellularly while the β subunit spans the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R have a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is a 60% homology between IGF1R and the insulin receptor. In response to ligand binding, the α chains induce the tyrosine autophosphorylation of the β chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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