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Your Position: Home > Cytokines > Complement Component C2 > Human Complement Component C2 Protein, His Tag

Human Complement Component C2 Protein, His Tag

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  • Synonym
    C2,Complement C2,Complement Component C2
  • Source
    Human C2, His Tag (CO2-H52H7) is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Leu 752 (Accession # P06681-1).
    Predicted N-terminus: Ala 21
  • Molecular Characterization
    Online-Res(Ala 21 - Leu 752) P06681-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 83.0 kDa.

  • Endotoxin
  • Formulation

    Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl, 5 mM CaCl2, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss was observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    C2 is a major histocompatibility complex class-III protein. Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. The lectin (LP) and classical (CP) pathways are two of the three main activation cascades of the complement system. These pathways start with recognition of different pathogen- or danger-associated molecular patterns and include identical steps of proteolytic activation of complement component C4, formation of the C3 proconvertase C4b2, followed by cleavage of complement component C2 within C4b2 resulting in the C3 convertase C4b2a.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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