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Your Position: Home > Cytokines > Complement component 3 > CO3-C52H5

Cynomolgus Complement component 3 / Complement C3 Protein, His Tag

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  • Synonym
    Complement C3,CPAMD1
  • Source
    Cynomolgus Complement component 3, His Tag (CO3-C52H5) is expressed from human 293 cells (HEK293). It contains AA Thr 23 - Asn 1663 (Accession # G7PYU9-1).
    Predicted N-terminus: Thr 23
  • Molecular Characterization
    Online-Res(Thr 23 - Asn 1663) G7PYU9-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 186.1 kDa.

  • Endotoxin
  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -22°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    C3 is the major complement component serum. It is mainly synthesized by macrophages and liver. C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. It is cleaved into two fragments, C3a and C3b. C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
  • Clinical and Translational Updates
      
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Price(USD) : $350.00

Price(USD) : $2310.00

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