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Your Position: Home > Cytokines > IL23A & IL12B > ILB-H5219

Human IL-23 alpha & IL-12 beta Heterodimer Protein, Tag Free

This product is still under development. Please contact us if you have interest in this product. We will accelerate the development process accordingly and reserve this product for you as request.
  • Synonym
    IL-23 alpha & IL-12 beta
  • Source
    Human IL-23A&IL-12B Heterodimer Protein (ILB-H5219) is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Ser 328 (IL-23A) & Arg 20 - Pro 189 (IL-12B) (Accession # Q9NPF7-1(IL23A) & P29460-1(IL12B)).
    Predicted N-terminus: Ile 23
  • Molecular Characterization
    Online-Res(Ile 23 - Ser 328 (IL-23A) & Arg 20 - Pro 189 (IL-12B)) Q9NPF7-1 (IL23A) & P29460-1 (IL12B)

    This protein carries no "tag".

    The protein has a calculated MW of 55.8 kDa.

  • Endotoxin
  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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