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Your Position: Home > Protein > S1PR5 > S15-H52P7

Human S1PR5 / EDG8 Full Length Protein (VLP)

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This product is still under development. Please contact us if you have interest in this product. We will accelerate the development process accordingly and reserve this product for you as request.
  • Synonym
    EDG8,Edg-8,S1P5,SPPR-1,SPPR-2
  • Source
    Human S1PR5 Full Length Protein (VLP)(S15-H52P7) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Asp 398 (Accession # Q9H228-1).
  • Molecular Characterization

    Virus-like particles(VLPs) are formed by self-assembly of envelop/capsid proteins from viruses. Membrane Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.

    The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.

  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 12 months under sterile conditions.
*The isotype control of empty/mock VLP (Cat. No. VLP-N5213) is sold separately and not included in protein, you can follow this link for product information.
  • Background
    Sphingosine-1-phosphate (S1P) is a bioactive lipid metabolite that exerts its actions by engaging 5 G-protein-coupled
    receptors (S1PR1-S1PR5). S1P receptors are involved in several cellular and physiological events, including lymphocyte/
    hematopoietic cell trafcking. An S1P gradient (low in tissues, high in blood), maintained by synthetic and degradative
    enzymes, regulates lymphocyte trafcking. Because lymphocytes live long (which is critical for adaptive immunity) and
    recirculate thousands of times, the S1P-S1PR pathway is involved in the pathogenesis of immune-mediated diseases.
  • Clinical and Translational Updates

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Drug Development Status

  • Number of Launched Drugs:5 Details
  • Number of Drugs in Clinical Trials:0 Details
  • Latest Research Phase:Approved

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