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Your Position: Home > Antibody > P16 > HGS-S315

Recombinant Monoclonal Anti-P16 Antibody, Rabbit (4A7)

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  • Background
    P16 is a member of the Ser/Thr protein kinase family. This protein is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers.
  • Host Species

    Rabbit

  • Clone

    4A7

  • Application

    IHC

  • Property
    1:1000
  • State
    Liquid
  • Positive Control
    Human Tonsil Tissue
  • Clonality
    Monoclonal
  • Synonym
    P16, CDK4
  • Research Field
    Cancer Drug Targets
  • Source
    Rabbit
  • Isotype
    IgG
  • Storage
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Typical Data
Control Sample
 P16 CONTROL SAMPLE

Immunohistochemical analysis of paraffin embedded Human Tonsil Tissue labelled with HGS-S315 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Cancer Sample
 P16 CANCER SAMPLE P16 CANCER SAMPLE P16 CANCER SAMPLE

Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HGS-S315 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

  • Clinical and Translational Updates

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