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Your Position: Home > Protein > Activin RIA > ACA-H5254

Human Activin RIA Protein, Fc Tag (MALS verified)

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  • Synonym
    ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI
  • Source
    Human Activin RIA Protein, Fc Tag(ACA-H5254) is expressed from human 293 cells (HEK293). It contains AA Met 21 - Glu 123 (Accession # Q04771).
    Predicted N-terminus: Met 21
  • Molecular Characterization
    Activin RIA Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 37.9 kDa. The protein migrates as 43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Activin RIA SDS-PAGE

Human Activin RIA Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS
Activin RIA MALS images

The purity of Human Activin RIA Protein, Fc Tag (Cat. No. ACA-H5254) is more than 85% and the molecular weight of this protein is around 70-90 kDa verified by SEC-MALS.

  • Background
    Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
  • Clinical and Translational Updates

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