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Your Position: Home > FGL1 A Novel Immune Inhibitor of LAG-3

FGL1 Protein: A Hot Immune Inhibitory Ligand of LAG-3

FGL1
Background

FGL1 is a member of the fibrinogen protein family, which is expressed at low levels in the liver under normal circumstances. But it is highly expressed in many types of cancers such as prostate cancer and melanoma. The latest research shows that FGL1 is a hot immune inhibitory ligand of LAG-3. Blocking FGL1 / LAG-3 interaction can improve the body's immunity and slow down tumor growth.

ACROBiosystems has developed FGL1 protein expressed by HEK293 with a variety of species (Human, Mouse, Cyno) and tags (Fc, His), and AviTagTM biotinylated FGL1 protein can help your drug development. ACRO has verified the purity and activity of FGL1 protein and protocols are offered.

Application
Product List
MoleculeCat. No.HostProduct Description

FGL1 

(HEK293 expressed)

FG1-H52HyHumanFGL1 Protein, His Tag
FG1-H5258HumanFGL1 Protein, Fc Tag
FG1-H82F4HumanBiotinylated FGL1 Protein, Avitag™,Fc Tag
FG1-C5269Cynomolgus / Rhesus macaqueFGL1 Protein, Fc Tag
FG1-H82EyHumanBiotinylated FGL1 Protein, His, Avitag™

FGL1 has been identified as a hot immune inhibitory ligand of LAG-3 products. If you are interested in LAG-3, please click here for more information.

Bioactivity

Bioactivity of FGL1 was validated by Cell-based assay, BLI and ELISA

Immobilized Human LAG-3, Mouse IgG2a Fc Tag (Cat. No. LA3-H52Aa) at 10 μg/mL (100 μL/well) can bind Human FGL1, Fc Tag (Cat. No. FG1-H5258) with a linear range of 0.02-0.156 μg/mL.

Serial dilutions of Anti-LAG3, Neutralizing Antibody were added into Human FGL1, Fc Tag (Cat. No. FG1-H5258): Biotinylated Human LAG-3, Mouse IgG2a Fc,Avitag (Cat. No. LA3-H82F3) binding reactions. The half maximal inhibitory concentration (IC50) is 0.42303 μg/mL.

FACS assay shows that Human FGL1, His Tag (Cat. No. FG1-H52Hy) can bind to 293T cells overexpressing human LAG3. The concentration of Human FGL1 is 20 μg/mL.

Loaded Human LAG-3, Fc Tag (Cat. No. LA3-H5255) on Protein A Biosensor, can bind Human FGL1, His Tag (Cat. No. FG1-H52Hy) with an affinity constant of 13.6 nM as determined in BLI assay (ForteBio Octet Red96e).

* If you would like ACRO to add more experimental design and application data of FGL1,please contact us.
* If you have any customized product or more suggestion for FGL1 protein, please click development suggestion.

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