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Your Position: Home > FGL1 A Novel Immune Inhibitor of LAG-3

FGL1 Protein: A Hot Immune Inhibitory Ligand of LAG-3

PD1 Pathway
Background

FGL1 is a member of the fibrinogen protein family, which is expressed at low levels in the liver under normal circumstances. But it is highly expressed in many types of cancers such as prostate cancer and melanoma. The latest research shows that FGL1 is a hot immune inhibitory ligand of LAG-3. Blocking FGL1 / LAG-3 interaction can improve the body's immunity and slow down tumor growth.

ACROBiosystems has developed FGL1 protein expressed by HEK293 with a variety of species (Human, Mouse, Cyno) and tags (Fc, His), and AviTagTM biotinylated FGL1 protein can help your drug development. ACRO has verified the purity and activity of FGL1 protein and protocols are offered.

Application
Product List
MoleculeCat. No.HostProduct DescriptionProduct Status

FGL1 

(HEK293 expressed)

FG1-H5253HumanHuman FGL1 Protein, Fc TagLaunched
FG1-H82F3HumanBiotinylated Human FGL1 Protein, Fc Tag, Avi Tag (Avitag™)
FG1-M5255MouseMouse FGL1 Protein, Fc Tag
FG1-C5253Cynomolgus / Rhesus macaqueCynomolgus / Rhesus macaque FGL1 Protein, Fc Tag
FG1-H52H7HumanHuman FGL1 Protein, His TagComing soon
FG1-H82E5HumanBiotinylated Human FGL1 Protein, His Tag, Avi Tag (Avitag™)
FG1-M5253MouseMouse FGL1 Protein, Mouse IgG2a Fc Tag
FG1-C5256Cynomolgus / Rhesus macaqueCynomolgus / Rhesus macaque FGL1 Protein, Mouse IgG2a Fc Tag

FGL1 has been identified as a hot immune inhibitory ligand of LAG-3 products. If you are interested in LAG-3, please click here for more information.

Bioactivity

Bioactivity of FGL1 was validated by ELISA

Immobilized Human LAG-3, mouse IgG2a Fc tag (Cat. No. LA3-H52Aa) at 10 μg/mL (100 μL/well) can bind Biotinylated Human FGL1, Fc Tag, Avi Tag (Cat. No. FG1-H82F3) with a linear range of 0.156-1.25 μg/mL.

Immobilized Human LAG-3, mouse IgG2a Fc tag (Cat. No. LA3-H52Aa) at 20 μg/mL (100 μL/well) can bind Human FGL1, Fc Tag (Cat. No. FG1-H5253) with a linear range of 5-78 ng/mL.

Immobilized Mouse LAG-3, His Tag (Cat. No. LA3-M52H5) at 20 μg/mL (100 μL/well) can bind Mouse FGL1, Fc Tag (Cat. No. FG1-M5255) with a linear range of 0.078-1.25 μg/mL.

Immobilized Human LAG-3, mouse IgG2a Fc tag (Cat. No. LA3-H52Aa) at 5 μg/mL (100 μL/well) can bind Cynomolgus / Rhesus macaque FGL1, Fc Tag (Cat. No. FG1-C5253) with a linear range of 8-125 ng/mL.

* If you would like ACRO to add more experimental design and application data of FGL1,please contact us.
* If you have any customized product or more suggestion for FGL1 protein, please click development suggestion.

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