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LAG-3

LAG-3 Molecule Information

Name:Lymphocyte activation gene 3 protein
Target Synonym:LAG-3?CD223?FDC?LAG3?Protein FDC
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:15
Lastest Research Phase:Phase ?

LAG-3 Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
LA3-HP2H3 Human PE-Labeled Human LAG-3 / CD223 Protein, His Tag (recommended for neutralizing assay)
LA3-HP2H3-structure
LA3-H82Fb Human Biotinylated Human LAG-3 / CD223 Protein, Fc,Avitag™
LA3-H82Fb-structure
LA3-H82Fb-sds
LA3-H82Fb-elisa_1
LA3-H82E5 Human Biotinylated Human LAG-3 / CD223 Protein, His,Avitag™
LA3-H82E5-structure
LA3-H82E5-sds
LA3-H82E5-elisa_1
LA3-H525c Human Human LAG-3 / CD223 Protein, Llama IgG2b Fc Tag, low endotoxin
LA3-H525c-structure
LA3-H525c-sds
LA3-H525c-elisa_1
LA3-H522a Human Human LAG-3 / CD223 Protein, low endotoxin
LA3-H522a-structure
LA3-H522a-sds
LA3-H522a-elisa_1
LA3-H82F3 Human Biotinylated Human LAG-3 / CD223 Protein, Mouse IgG2a Fc,Avitag™
LA3-H82F3-structure
LA3-H82F3-sds
LA3-H82F3-elisa_1
LA3-M52Ha Marmoset Marmoset LAG-3 / CD223 Protein
LA3-M52Ha-structure
LA3-M52Ha-sds
LA3-M52Ha-elisa_1
LA3-H52Aa Human Human LAG-3 / CD223 Protein, Mouse IgG2a Fc Tag
LA3-H52Aa-structure
LA3-H52Aa-sds
LA3-H52Aa-elisa_1
LA3-C52A0 Cynomolgus Cynomolgus LAG-3 / CD223 Protein, Mouse IgG2a Fc Tag
LA3-C52A0-structure
LA3-C52A0-sds
LA3-C52A0-elisa_1
LA3-C5252 Cynomolgus Cynomolgus LAG-3 / CD223 Protein, Fc Tag
LA3-C5252-structure
LA3-C5252-sds
LA3-C5252-elisa_1
LA3-H5255 Human Human LAG3 / CD223 Protein, Fc Tag (HPLC-verified)
LA3-H5255-structure
LA3-H5255-sds
LA3-H5255-hplc
LA3-H5255-elisa_1
LA3-M52H5 Mouse Mouse LAG-3 / CD223 Protein, His Tag
LA3-M52H5-structure
LA3-M52H5-sds
LA3-R52H5 Rat Recombinant Rat LAG3 /CD223 Protein
LA3-R52H5-structure
LA3-R52H5-sds
LA3-H5222 Human Human LAG-3 / CD223 Protein, His Tag
LA3-H5222-structure
LA3-H5222-sds
LA3-H5222-elisa_1
LA3-H5222-elisa_2

LAG-3 Molecule Synonym Name

LAG3,CD223,FDC

LAG-3 Molecule Background

Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.

LAG-3 References

LAG-3 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Anti-LAG-3 mAb (Regeneron Pharmaceuticals/Sanofi) REGN-3767 Phase Ⅰ Regeneron Pharmaceutical, Sanofi Malignancies Details
Nivolumab/Relatlimab BMS-936558/BMS-986016; BMS-986213 Phase Ⅲ Bristol-Myers Squibb Melanoma Details
Chlorogenic acid Phase Ⅲ Sichuan Jiuzhang Biotech Glioblastoma Details
TSR-033 TSR-033,TSR 033,TSR033 Phase Ⅰ AnaptysBio, Tesaro, GlaxoSmithKline Solid tumours Details
BI-754111 BI-754111 Phase Ⅱ Boehringer Ingelheim Non small cell lung cancer (NSCLC), Solid tumours, Head and neck cancer Details
Ieramilimab LAG-525; IMP-701 Phase Ⅱ Immutep, Novartis, CoStim Triple negative breast cancer, Neuroendocrine tumors (NET), Small cell lung cancer (SCLC), Gastric adenocarcinoma, Diffuse large B cell lymphoma, Esophageal adenocarcinoma, Castration-resistant prostate cancer (CRPC), Solid tumours, Soft tissue sarcoma, Ovarian cancer, Hematological cancer, Melanoma Details
IMP-761 IMP-761 Preclinical Immutep Autoimmune diseases Details
IBI110 IBI110,IBI-110 IND Filing Innovent Biologics Cancer Details
XmAb-22841 XmAb-22841 Phase Ⅰ Xencor Cancer Details
FS 118 FS-118 Phase Ⅰ F-star, Merck Serono hematological malignancies, Solid tumours Details
Relatlimab BMS-986016; ONO-4482 Phase Ⅲ Bristol-Myers Squibb, Ono Pharmaceutical Melanoma Details
Sym-022 Sym-022 Phase Ⅰ Symphogen Solid tumours, Lymphoma Details
MGD-013 MGD-013,PD-1 X LAG-3,MGD013; MGD 013 Phase Ⅰ MacroGenics, Zai Lab hematological malignancies, Solid tumours Details
GSK-2831781 GSK-2831781; ImmuTune-IMP731; IMP-731, GSK2831781; IMP731 ,GSK‘781 Phase Ⅱ Prima BioMed, GlaxoSmithKline Ulcerative colitis Details
INCAGN-2385 INCAGN-02385; INCAGN-2385 Phase Ⅰ Agenus Solid tumours Details

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