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TNF-alpha

TNF-alpha Molecule Information

Name:Tumor necrosis factor ?
Target Synonym:Intracellular domain 1;NTF;Cachectin;TNF-a;TNFSF2;ICD2;TNF;Intracellular domain 2;TNF-alpha;N-terminal fragment;Tumor necrosis factor ligand superfamily member 2;TNFA ;Tumor necrosis factor;Tumor necrosis factor, soluble form;Tumor necrosis factor, membra
Number of Launched Drugs:39
Number of Drugs in Clinical Trials:132
Lastest Research Phase:Approved

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TNF-alpha Part of Bioactivity data

TNA-H5228-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Human TNF-alpha, His Tag (active trimer) (MALS verified) (Cat. No. TNA-H5228) induces cytotoxicity effect on the WEH1-13VAR cells in the presence of the metabolic inhibitor actinomycin D. The EC50 for this effect is 0.013-0.074 ng/mL (Routinely tested).

TNA-H5228-Cell-based assay
Human FcRn Heterodimer Protein Cell_Base

Neutralization assay shows that the cytotoxicity effect of Human TNF-alpha, His Tag (active trimer) (MALS verified) (Cat. No. TNA-H5228) was inhibited by increasing concentration of Adalimumab. The concentration of TNF-alpha used is 1 ng/mL. The IC50 is 26.8 ng/mL (Routinely tested).

TNA-H5228-SPR
Human_FcRn_Heterodimer_Protein_SPR

Humira (Adalimumab) captured on CM5 chip via anti-human IgG Fc antibodies surface, can bind Human TNF-alpha, His Tag (active trimer) (MALS verified) (Cat. No. TNA-H5228) with an affinity constant of 0.244 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

TNA-H4211-SPR
Human_FcRn_Heterodimer_Protein_SPR

Humira (Adalimumab) captured on CM5 chip via anti-human IgG Fc antibodies surface, can bind ActiveMax® Human TNF-alpha, Tag Free, low endotoxin (active trimer) (MALS verified) (Cat. No. TNA-H4211) with an affinity constant of 0.255 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

TNF-alpha Molecule Synonym Name

DIF,TNF-alpha,TNFA,TNFSF2,cachexin,cachectin,TNF¦Á

TNF-alpha Molecule Background

Tumor necrosis factor alpha (TNF¦Á)is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNF¦Á is in the regulation of immune cells. TNF¦Á is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNF¦Á production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNF¦Á is used as an immunostimulant under the INN tasonermin. TNF¦Á can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

TNF-alpha References

TNF-alpha Public Drug Information

NameResearch CodeResearch PhaseCompanyFirst Brand NameFirst Approved CountryFirst IndicationFirst Approved CompanyFirst Approved DateIndicationsClinical Trials
Etanercept biosimilar (Hanwha Chemical)HD-203; MK-8953ApprovedHanwha Chemical




Ankylosing Spondylitis (AS), Plaque psoriasis, Psoriatic arthritis, Rheumatoid arthritis (RA)Details
Etanercept-szzsGP-2015ApprovedSandozERELZIfdaJuvenile idiopathic arthritis (JIA), Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA)SANDOZ2016-08-30Juvenile idiopathic arthritis (JIA), Spondyloarthritis, Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA)Details
InfliximabTA-650ApprovedJanssen, Merck Sharp & Dohme, Mitsubishi Tanabe PharmaREMICADEfdaUlcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's diseaseCENTOCOR INC1998-08-24Pediatric ulcerative colitis, Psoriasis vulgaris, Crohn's disease, Mucocutaneous lymph node syndrome (Kawasaki syndrome), Psoriatic erythroderma, Ankylosing Spondylitis (AS), Uveitis, Pustular psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Behcet's disease, Pediatric Crohn's diseaseDetails
Etanercept biosimilar (Nanogen Biopharmaceutical)
ApprovedNanogen Biopharmaceutical Co




Psoriasis, Rheumatoid arthritis (RA)Details
Adalimumab biosimilar (AXXO)
ApprovedAXXO




Psoriatic arthritis, Rheumatoid arthritis (RA)Details
Etanercept biosimilar (AryoGen Biopharma)
ApprovedAryoGen Biopharma




Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)Details
Certolizumab pegolCZP; CDP-870; PHA-738144,CDP870,PHA738144ApprovedUCBCIMZIAfdaPsoriatic arthritis, Rheumatoid arthritis (RA), Crohn's diseaseUCB INC2008-04-22Plaque psoriasis, Spondyloarthritis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's diseaseDetails
Etanercept biosimilar (PROBIOMED)
ApprovedProbiomed




Rheumatoid arthritis (RA)Details
EtanerceptTNR-001ApprovedAmgen, Pfizer, Takeda, Boehringer IngelheimENBRELfdaPediatric plaque psoriasis, Plaque psoriasis, Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)IMMUNEX1998-11-02Juvenile idiopathic arthritis (JIA), Pediatric plaque psoriasis, Spondyloarthritis, Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriasis, Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)Details
Adalimumab biosimilar (Zydus Cadila)
ApprovedZydus cadila




Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)Details
Etanercept biosimilar (Shanghai CP Guojian Pharmaceutical)
ApprovedShanghai CP Guojian, Cipla
cfdaAnkylosing Spondylitis (AS), Rheumatoid arthritis (RA), Plaque psoriasis
2015-01-27Plaque psoriasis, Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)Details
Etanercept biosimilar (Samsung Bioepis)SB-4ApprovedSamsung Bioepisetanerceptema
Samsung Bioepis NL B.V.2016-01-13Juvenile idiopathic arthritis (JIA), Spondyloarthritis, Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA)Details
Adalimumab biosimilar (Fujifilm Kyowa Kirin Biologics/Mylan)FKB-327ApprovedFujifilm Kyowa Kirin Biologics, Mylanadalimumabema
Mylan S.A.S.2018-09-16Plaque psoriasis, Uveitis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriasis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)Details
Adalimumab biosimilar (Biocad)BCD-057ApprovedBiocad




Plaque psoriasisDetails
Adalimumab biosimilar (Sandoz)GP-2017ApprovedSandozadalimumabema
Sandoz GmbH2018-07-26Juvenile idiopathic arthritis (JIA), Uveitis, Spondyloarthritis, Pediatric plaque psoriasis, Ulcerative colitis, Psoriasis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's diseaseDetails
PomalidomideCC-4047; CDC-394; IMID-4047; IMiD-1ApprovedCelgenePOMALYSTfdaMultiple myeloma (MM)CELGENE2013-02-08Multiple myeloma (MM)Details
Infliximab biosimilar (Bionovis/The Instituto Vital Brazil)
ApprovedBionovis, The Instituto Vital Brazil




Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's diseaseDetails
Etanercept biosimilar (Intas Biopharmaceuticals)
ApprovedIntas Biopharmaceuticals




Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)Details
Etanercept biosimilar (Mochida)LBEC-0101ApprovedMochida, Ayumi
日本Rheumatoid arthritis (RA), Juvenile idiopathic arthritis (JIA)持田制药2018-01-19 00:00:00.0Juvenile idiopathic arthritis (JIA), Rheumatoid arthritis (RA)Details
Adalimumab-adbmBI-695501ApprovedBoehringer IngelheimCYLTEZOfdaJuvenile idiopathic arthritis (JIA), Ankylosing Spondylitis (AS), Plaque psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's diseaseBOEHRINGER INGELHEIM2017-08-25Juvenile idiopathic arthritis (JIA), Uveitis, Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA)Details
GolimumabCNTO-148; rTNV148B,CNTO148ApprovedJanssen, Merck Sharp & Dohme, Mitsubishi Tanabe PharmaSIMPONIfdaUlcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA)CENTOCOR ORTHO BIOTECH INC2009-04-24Juvenile idiopathic arthritis (JIA), Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA)Details
Infliximab biosimilar (Amgen)ABP-710ApprovedAmgenAVSOLAfda
AMGEN INC2019-12-06Ankylosing Spondylitis (AS), Pediatric ulcerative colitis, Ulcerative colitis, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA), Pediatric Crohn's diseaseDetails
Infliximab (ABDA)SB-2ApprovedSamsung Bioepis, Merck Sharp & Dohmeinfliximabema
Samsung Bioepis NL B.V.2016-05-26Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease, Pediatric Crohn's diseaseDetails
Infliximab-qbtxPF-06438179; PF-6438179; GP-1111,PF06438179; PF6438179ApprovedPfizer, SandozIXIFIfda
PFIZER INC2017-12-13Psoriatic erythroderma, Ankylosing Spondylitis (AS), Plaque psoriasis, Pustular psoriasis, Ulcerative colitis, Psoriatic arthritis, Psoriasis vulgaris, Crohn's disease, Rheumatoid arthritis (RA), Pediatric Crohn's diseaseDetails
PentoxifyllineBL-191; EHT-0201; EHT-201ApprovedUs Pharm HoldingsTRENTALfda
US PHARM HOLDINGS1984-08-30Peripheral vascular disordersDetails
Infliximab (dyyb)CT-P13,CTP13ApprovedCelltrion, Hospira, Nippon Kayakuinfliximabema
Pfizer Europe MA EEIG2013-09-09Psoriatic erythroderma, Plaque psoriasis, Ankylosing Spondylitis (AS), Pustular psoriasis, Psoriasis, Ulcerative colitis, Psoriatic arthritis, Psoriasis vulgaris, Rheumatoid arthritis (RA), Crohn's disease, Pediatric Crohn's diseaseDetails
Adalimumab biosimilar (Fresenius Kabi)MSB-11022ApprovedMerck Serono, Fresenius Kabiadalimumabema
Fresenius Kabi Deutschland GmbH2019-04-02Uveitis, Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease, Juvenile rheumatoid arthritis (JRA)Details
Etanercept biosimilar (Hisun-Pfizer Pharmaceuticals)
ApprovedHisun-Pfizer




Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA)Details
PG-201PG-201,PG 201ApprovedViroMed, PMG Pharm




Osteoarthritis (OA)Details
Infliximab biosimilar (Nichiiko Pharmaceutical/Aprogen)GS-071; NI-071ApprovedNichi-Iko Pharmaceutical, Aprogen, Zeria, AyumiInfliximab biosimilar (Nichiiko Pharmaceutical/Aprogen)日本Rheumatoid arthritis (RA), Psoriasis vulgaris, Psoriatic arthritis, Pustular psoriasis, Crohn's disease, Ulcerative colitisNichi-Iko Pharmaceutical,Zeria2017-09-27 00:00:00.0Pustular psoriasis, Ulcerative colitis, Psoriatic arthritis, Psoriasis vulgaris, Crohn's disease, Rheumatoid arthritis (RA)Details
Luminol sodiumMP-1032,MP1032ApprovedMetrio, Selvim




Psoriasis, Immunological disordersDetails
Adalimumab-afzbPF-06410293ApprovedPfizerABRILADAfda
PFIZER INC2019-11-15Juvenile idiopathic arthritis (JIA), Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA)Details
Adalimumab biosimilar (Amgen)ABP-501ApprovedAmgen, Daiichi SankyoAMJEVITAfdaJuvenile idiopathic arthritis (JIA), Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA)AMGEN INC2016-09-23Juvenile idiopathic arthritis (JIA), Uveitis, Ankylosing Spondylitis (AS), Plaque psoriasis, Ulcerative colitis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA)Details
Adalimumab biosimilar (Samsung Bioepis)SB-5ApprovedSamsung Bioepisadalimumabema
Samsung Bioepis NL B.V.2017-08-24Pediatric plaque psoriasis, Spondyloarthritis, Hidradenitis suppurativa, Crohn's disease, Juvenile idiopathic arthritis (JIA), Uveitis, Ankylosing Spondylitis (AS), Psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Pediatric Crohn's diseaseDetails
LenalidomideCDC-501; CC-5013; CDC-5013; ENMD-0997; IMID-5013; IMiD-3ApprovedCelgene, BeiGeneREVLIMIDfdaMyelodysplastic syndrome (MDS), Mantle cell lymphoma (MCL), Multiple myeloma (MM)CELGENE2005-12-27Myelodysplastic syndrome (MDS), Mantle cell lymphoma (MCL), Multiple myeloma (MM), Peripheral T cell lymphoma (PTCL)Details
AdalimumabD2E7; LU-200134;ABT-D2E7ApprovedAbbvieHUMIRAfda
ABBVIE INC2002-12-31Spondyloarthritis, Hidradenitis suppurativa, Crohn's disease, Juvenile idiopathic arthritis (JIA), Ankylosing Spondylitis (AS), Plaque psoriasis, Uveitis, Pustular psoriasis, Psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA), Pediatric Crohn's diseaseDetails
Infliximab biosimilar (Reliance Life Sciences)BOW-015; R-TPR-015ApprovedEPIRUS Biopharmaceuticals, Sun Pharmaceutical




Rheumatoid arthritis (RA)Details
Adalimumab biosimilar (Bio-Thera Solutions)BAT-1406ApprovedBio-Thera SolutionsAdalimumab InjectioncfdaAnkylosing Spondylitis (AS), Rheumatoid arthritis (RA), Psoriasis
2019-11-04Ankylosing Spondylitis (AS), Psoriasis, Rheumatoid arthritis (RA)Details
Infliximab biosimilar (AXXO)
ApprovedAXXO




Autoimmune diseases, Crohn's diseaseDetails
Adalimumab biosimilar (Hisun Pharma)HS-016,HS016ApprovedHisun PharmAdalimumab Solution for InjectioncfdaAnkylosing Spondylitis (AS)
2019-12-06Plaque psoriasis, Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)Details
Etanercept biosimilar (Amega Biotech)
ApprovedAmega Biotech




Rheumatoid arthritis (RA)Details
Etanercept biosimilar (Mylan)YLB-113ApprovedLupin, Mylan, YL Biologicsetanerceptema
Mylan IRE Healthcare Limited2020-05-20Plaque psoriasis, Spondyloarthritis, Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)Details
Etanercept biosimilar (Mycenax Biotech/TSH Biopharm)E-11; ENIA-11,E11; ENIA11ApprovedMycenax Biotech, TSH Biopharm




Rheumatoid arthritis (RA)Details
Adalimumab biosimilar (Reliance Life Sciences)R-TPR-021ApprovedReliance Life Sciences, Torrent Pharmaceuticals




Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA)Details
ThalidomideNSC-527179; NSC-66847; K-17,NSC527179; NSC66847; K17,NSC 527179; NSC 66847; K 17ApprovedCelgeneTHALOMIDfdaErythema nodosum leprosum (ENL), Multiple myeloma (MM)CELGENE1998-07-16Erythema nodosum leprosum (ENL), Multiple myeloma (MM)Details
Anti-tumour necrosis factor-alpha antibody
ApprovedMateria Medica Holding Research and Production Company




Osteoarthritis (OA), Rheumatoid arthritis (RA)Details

TNF-alpha Clinical Drug Information

NameResearch CodeResearch PhaseCompanyIndicationsClinical Trials
tgAAC 94
Phase ⅡArmata PharmaceuticalsRheumatoid arthritis (RA), Periodontal diseaseDetails
Infliximab biobetter (Mabtech/Sorrento)STI-002Phase ⅢTaizhou Mabtech, Sorrento TherapeuticsRheumatoid arthritis (RA)Details
CMAB815CMAB815,CMAB-815; CMAB 815IND FilingShanghai Biomabs, SinoMab Bioscience LtdRheumatoid arthritis (RA)Details
Human TNF-α monoclonal antibody( Simcere Pharmaceutical)
IND FilingNanjing XianSheng Dongyuan Pharmaceutical, Shandong Xiansheng Medejin Bio-pharmaceutical, SimcereUnspecifiedDetails
Recombinant anti-TNFα monoclonal antibody (Wuhan Institute of Biological Products)
Phase ⅠWuhan Institute of Biological ProductsPlaque psoriasis, Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)Details
Recombinant anti-TNFα antibody (Shanghai Xiesheng Medicine)
Phase ⅠShanghai Xiesheng Pharmaceutical TechnologyUnspecifiedDetails
Adalimumab biosimilar (Shanghai Maitaiyabo Biotech)
IND FilingShanghai Maitai Yabo Biological TechnologyRheumatoid arthritis (RA)Details
Hemay007Hemay-007Phase ⅡTianjin Hemay BiotechUlcerative colitisDetails
BLX-1002BLX-1002Phase ⅡOrchidType 2 diabetesDetails
Azacitidine/Lenalidomide
Phase ⅡCelgeneAcute myeloid Leukemia (AML)Details
Adalimumab biosimilar (Bionovis/The Instituto Vital Brazil)
Phase Not SpecifiedBionovis, The Instituto Vital BrazilPlaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's diseaseDetails
EYS-606EYS-606Phase ⅡEyevensysUveitisDetails
Infliximab biosimilar (Shanghai CP Guojian)
Phase ⅢShanghai CP GuojianRheumatoid arthritis (RA)Details
HMPL-004 (Hutchison Medipharma)HMPL-004Phase ⅢHutchison MedipharmaUlcerative colitis, Crohn's diseaseDetails
Recombinant anti-TNFα antibody (Sailemin Biotech)
IND FilingHainan Sailemin Biological TechnologyAnkylosing Spondylitis (AS), Rheumatoid arthritis (RA)Details
REN-1654CPI-1189; REN-1189; REN-1654,REN1654,REN1189,CPI1189Phase ⅡEvotecPostherpetic neuralgia (PHN), SciaticaDetails
Adalimumab biosimilar (LG Life Sciences)LBALPhase ⅢLG Chem, MochidaRheumatoid arthritis (RA)Details
Adalimumab biosimilar (Beijing Luzhu Biotechnology)
Phase ⅠBeijing Luzhu BiotechnologyRheumatoid arthritis (RA)Details
ONO-4007ONO-4007Phase ⅡOno PharmaceuticalCancer chemotherapyDetails
Recombinant human anti-TNFα monoclonal antibody (Taizhou Mabtech)
IND FilingTaizhou MabtechUnspecifiedDetails
PUR-0110PUR-0110; PCT-233Phase ⅢPurGenesis TechnologiesRadiodermatitisDetails
ISIS-104838ISIS 104838Phase ⅡIonisPsoriasis, Rheumatoid arthritis (RA)Details
CC-10015CC-10015Phase ⅡCelgeneSarcoidosisDetails
LP-0058LP-0058; LEO-32731,LP0058,LEO32731Phase ⅡLeo PharmaPsoriasis, Atopic dermatitisDetails
GSK-2800528GSK-2800528,GSK 2800528,GSK2800528Phase ⅠGlaxoSmithKlinePsoriasis, InflammationDetails
Adalimumab biosimilar (Oncobiologics)ONS-3010Phase ⅢOutlook TherapeuticsPlaque psoriasisDetails
Adalimumab biosimilar (CTTQ Pharma)
BLA FilingChiatai Tianqing (CTTQ)Rheumatoid arthritis (RA)Details
QR-449QR-440; QR-443; QR-449Phase ⅠProPhase LabsCachexia, Metabolic disorders, PainDetails
Infliximab biosimilar (Shanghai Biomabs)CMAB-008BLA FilingShanghai BiomabsRheumatoid arthritis (RA)Details
HP-228HP-228; ILP-228Phase ⅡSygnisObesity, Type 2 diabetes, Postoperative pain, InflammationDetails
Adalimumab biosimilar (Coherus BioSciences)CHS-1420Phase ⅢCoherus BiosciencesPlaque psoriasisDetails
Adalimumab biosimilar (CinnaGen)
Phase ⅢCinnaGenRheumatoid arthritis (RA)Details
Infliximab biosimilar (Biocad)BCD-055Phase ⅢBiocadAnkylosing Spondylitis (AS), Rheumatoid arthritis (RA)Details
Infliximab biosimilar (Genor Biopharma)GB-242,GB242Phase ⅢGenor BiopharmaRheumatoid arthritis (RA)Details
CDP-571CDP-571; BAY-10-3356; cb-0010,CDP 571; BAY 10 3356; cb 0010,CDP571; BAY103356; cb0010Phase ⅢCelltech, BiogenType 2 diabetes, Septic shock, Rheumatoid arthritis (RA), Crohn's diseaseDetails
Recombinant anti-TNFα monoclonal antibody (Livzon Group)AT-132; LZM-001Phase ⅡLivzon Group Livzon Pharmaceutical FactoryRheumatoid arthritis (RA)Details
PlaculumabART-621; CEP-37247; PN-0621; Dom-0200Phase ⅡPeptech UK, Domantis, Arana, TevaPsoriasis, Inflammation, Rheumatoid arthritis (RA), SciaticaDetails
Recombinant human TNF-α monoclonal antibody (Sinocelltech)SCT-630Phase ⅢSinocelltechPlaque psoriasisDetails
AZD-9773 (BTG)
Phase ⅡBTG plc, AstraZenecaSeptic shock, SepsisDetails
JNJ-63823539JNJ-63823539Phase ⅠJanssenRheumatoid arthritis (RA)Details
MM-A01-01MM-A01-01,MMA0101Phase ⅡMyungmoon PharmRheumatoid arthritis (RA)Details
Etanercept biosimilar (Bionovis/The Instituto Vital Brazil)
Phase Not SpecifiedBionovis, The Instituto Vital BrazilPlaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA)Details
Hemay-005Hemay-005Phase ⅡTianjin Hemay Biotech, Hainan Hailing Chemipharma Corporation LimitedAnkylosing Spondylitis (AS), Plaque psoriasis, Psoriatic arthritis, Behcet's diseaseDetails
Adalimumab biosimilar (Alphamab)KN-002Phase ⅠAlphamabRheumatoid arthritis (RA)Details
Adalimumab biosimilar (Genor Biopharma)BCD-100; GB-232Phase ⅠGenor Biopharma, BiocadRheumatoid arthritis (RA)Details
Adalimumab biosimilar (Danhong Pharma)BC-002Phase ⅠDanhong PharmaPlaque psoriasis, Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)Details
NPH-30907NPH-30907Phase ⅡPiramal PhytocareFungal infectionDetails
Adalimumab biosimilar (Tonghua Dongbao Pharmaceutical)
Phase ⅢTonghua Dongbao PharmaceuticalPlaque psoriasisDetails
Adalimumab biosimilar (Shanghai Henlius Biotech)HLX-03BLA FilingShanghai Henlius BiotechPlaque psoriasis, Rheumatoid arthritis (RA)Details
Adalimumab biosimilar (Mylan/Biocon)BMO-2; MYL-1401-ABLA FilingBiocon, MylanPsoriasis, Rheumatoid arthritis (RA)Details
INDUS-83030INDUS-83030Phase Not SpecifiedIndus Biotech Private LimitedRheumatoid arthritis (RA)Details
AMG-548AMG-548Phase ⅠAmgenRheumatoid arthritis (RA), ArthritisDetails
Recombinant human anti-TNFα monoclonal antibody (Qilu Pharmaceutical)
Phase ⅠQilu PharmaceuticalAnkylosing Spondylitis (AS), Rheumatoid arthritis (RA)Details
Etanercept biosimilar (Zenotech Laboratories)
Phase Not SpecifiedZenotech laboratoriesRheumatoid arthritis (RA)Details
Adalimumab biosimilar (HEC Pharma)
IND FilingHEC PharmRheumatoid arthritis (RA)Details
Recombinant chimeric anti-TNFα antibody (Hisun Pharma)HS-626BLA FilingHisun PharmPlaque psoriasisDetails
ABT-122ABT-122; D2E7-GS10-B6-17Phase ⅡAbbvieRheumatic disorders, Psoriatic arthritisDetails
Tumour necrosis factor alpha kinoidTNF-K; TNF-K005Phase ⅡNeovacsRheumatoid arthritis (RA), Crohn's diseaseDetails
Etanercept biosimilar (Clover Biopharmaceuticals)SCB-808Phase ⅢClover BiopharmaceuticalsAnkylosing Spondylitis (AS), Rheumatoid arthritis (RA)Details
Etanercept biosimilar (Qilu Pharmaceutical)QL-0902BLA FilingQilu PharmaceuticalAnkylosing Spondylitis (AS), Rheumatoid arthritis (RA)Details
IBPM005IX (Inbiopro Solutions)
Phase Not SpecifiedInbiopro SolutionsAnkylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease, Juvenile rheumatoid arthritis (JRA)Details
Etanercept biosimilar (AvesthaGen)
Phase ⅢAvesthagenRheumatoid arthritis (RA)Details
K-832K-832Phase ⅡKowaRheumatoid arthritis (RA)Details
Adalimumab biosimilar (Momenta Pharmaceuticals)BAX-2923; M-923; BAX-923Phase ⅢMomenta, ShirePlaque psoriasis, Autoimmune diseases, Inflammation, Rheumatoid arthritis (RA)Details
AN-0128AN-0128; CRM-0005; ONT-0001,AN0128,ONT0001,CRM0005Phase ⅡAnacor PharmaceuticalsAtopic dermatitisDetails
V-565V-565Phase ⅡVHSquaredCrohn's diseaseDetails
Etanercept biosimilar (Shanghai Fudan-Zhangjiang Bio-Pharmaceutical)
BLA FilingShanghai Fudan-Zhangjiang Bio-PharmaceuticalRheumatoid arthritis (RA)Details
Anti-tumour necrosis factor alpha (Livzon)
Phase ⅠLivzon GroupAutoimmune diseasesDetails
Adalimumab with ENHANZE technology (Abbvie)
Phase ⅠAbbvieUnspecifiedDetails
Recombinant human anti-TNFα monoclonal antibody (Weimingdamu Biotech)
Phase ⅠAnhui Sinobioway Damu BiomedicineRheumatoid arthritis (RA)Details
AME-527AME-527Phase ⅡApplied Molecular EvolutionRheumatoid arthritis (RA)Details
YS-IL6YS-IL6; YSIL-6; YSIL6-O-RA; YSIL6-T-PSPhase ⅡY's TherapeuticsRheumatoid arthritis (RA)Details
OCT-B201OCT-B201; BT-201Phase ⅠOscotecOsteoarthritis (OA)Details
Certolizumab (Intrexon)AG-014Phase ⅠIntrexon CorporationInflammatory bowel diseaseDetails
DLX-105DLX-105; ESBA-105Phase ⅡESBATech, Cell MedicaUveitis, Plaque psoriasis, Crohn's disease, Dry eye diseaseDetails
Etanercept biosimilar (Biotrion)BT-D001Phase ⅢBiotrionRheumatoid arthritis (RA)Details
Etanercept biosimilar (Shanghai Celgen)
Phase ⅢShanghai Celgen BioPlaque psoriasisDetails
Adalimumab biosimilar (Innovent Biologics)IBI-303BLA FilingInnovent BiologicsAnkylosing Spondylitis (AS)Details
AVX-470AVX-1350; AVX-470; AVX-470hPhase ⅠAvaxia BiologicsUlcerative colitisDetails
COVA-322COVA-322Phase ⅡCovagenPlaque psoriasisDetails
CYT 007 TNFQb
Phase ⅡCytosPsoriasis, Rheumatoid arthritis (RA)Details
MNX-160LMP-160; MNX-160PreclinicalNonindustrial source, MacronexCachexia, Diabetes, Psoriasis, Multiple sclerosis (MS), Rheumatoid arthritis (RA), Asthma, Adult respiratory distress syndrome (ADRS)Details
KOB-03KOB-03Phase ⅡDong Wha PharmaceuticalsAllergic rhinitis (AR)Details
Adalimumab biosimilar (Alvotech)AVT-02 (Alvotech)Phase ⅢAlvotechPlaque psoriasis, Autoimmune diseasesDetails
BIRB-1017BIRB-1017Phase Not SpecifiedBoehringer IngelheimPsoriasis, Rheumatoid arthritis (RA)Details
Etanercept (Neurokine Pharmaceuticals)NK-001; NP-1Phase Not SpecifiedPivot PharmaceuticalsCognitive disordersDetails
ENMD-0995S-3APG; ENMD-0995Phase ⅠCelgene, Boston Children's HospitalMultiple myeloma (MM)Details
PMI-001PMI-001,PMI 001,PMI001Phase ⅢPhytomedicsLupus vulgaris, Psoriasis, Multiple sclerosis (MS), Rheumatoid arthritis (RA)Details
Recombinant anti-TNFα human monoclonal antibody (Jilin Kanghui Biotech)
IND FilingJilin Kanghui Biological TechnologyUnspecifiedDetails
Adalimumab biosimilar (Hualan Biological Engineering)
Phase ⅢHualan Biological EngineeringRheumatoid arthritis (RA)Details
Golimumab biosimilar (Bio-thera)BAT-2506Phase ⅠBio-Thera SolutionsAnkylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA)Details
OzoralizumabATN-103; PF-05230896; PF-5230896; TS-152Phase ⅢAblynx, Eddingpharm, Pfizer, Taisho PharmaceuticalRheumatoid arthritis (RA)Details
DOM-0215DOM-0215,Dom 0215,Dom0215PreclinicalGlaxoSmithKlineRheumatoid arthritis (RA)Details
Human anti-TNFα monoclonal antibody (DZM Biotech)
Phase ⅠDZM BiotechRheumatoid arthritis (RA)Details
YHB-1411-2YHB-1411-2; YHB1411-2; YHB-14112; MAb YHB1411-2Phase ⅠYuhan CorporationRheumatoid arthritis (RA)Details
LY-3114062LY-3114062; LY3114062Phase ⅠLillyArthritisDetails
Recombinant human monoclonal antibody specific for human tumor necrosis factor (North China Pharmaceutical)
Phase ⅠNorth China PharmaceuticalAnkylosing Spondylitis (AS), Rheumatoid arthritis (RA)Details
ABBV-257ABBV-257; DVD-1; DVD-Ig-1Phase ⅠAbbottRheumatoid arthritis (RA)Details
NV-52NV-52; NV-07βPhase ⅡNovogenUlcerative colitis, Crohn's disease, Inflammatory bowel diseaseDetails
LenerceptTNFR55-Ig1; RO-452081; p55TNFR-Ig; NFR55-IgG1Phase ⅢRocheSeptic shock, Rheumatoid arthritis (RA)Details
PF-5230905ATN-192;PF-05230905; PF-5230905Phase ⅠAblynxRheumatoid arthritis (RA)Details
TanfanerceptHBM-9036; HL-036Phase ⅢHanAll, Harbour BioMed, DaewoongDry eye diseaseDetails
Adalimumab biosimilar (Jiangsu Zhonghe)UBP-1211,UBP1211; UBP 1211Phase ⅢJiangsu Zhonghe Medicine, Shanghai Junshi BiosciencesRheumatoid arthritis (RA)Details
Adalimumab biosimilar (Celltrion)CT-P17Phase ⅢCelltrionRheumatoid arthritis (RA)Details
Anti-TNFalpha polyclonal antibody (Verigen)
Phase ⅡGenzyme, ItalchimiciCrohn's disease, Rheumatoid arthritis (RA)Details
Etanercept biosimilar (Coherus Biosciences)BAX-2200; CHS-0214Phase ⅢCoherus Biosciences, Daiichi SankyoPlaque psoriasis, Rheumatoid arthritis (RA)Details
SA-13353DE-096; SA-13353,DE096,SA13353Phase ⅡSanten, AyumiRheumatoid arthritis (RA), Diabetic macular edemaDetails
Adalimumab biosimilar (Dong-A ST/Meiji Seika Pharma)DA-3113; DMB-3113Phase ⅠDong-A Pharmaceutical, Meiji Seika PharmaRheumatoid arthritis (RA)Details
Ro-327315Ro-327315; Ro-32-7315Phase ⅠRocheRheumatoid arthritis (RA)Details
Recombinant mutant human tumor necrosis factor alpha (State Key Laboratory of Cancer Biology)
Phase ⅡState Key Laboratory of Cancer BiologyGastric cancer, Colorectal cancer, Lung cancer, Renal carcinoma, Head and neck cancerDetails
Recombinant humanized anti-TNFα monoclonal antibody (Shenzhen Main Luck Pharmaceuticals)
IND FilingShenzhen Main Luck PharmaceuticalsAnkylosing Spondylitis (AS), Rheumatoid arthritis (RA)Details
ABX-0401ABX-0401Phase ⅡSanofi, PfizerImmune-inflammatory diseases, Rheumatoid arthritis (RA), Inflammatory bowel diseaseDetails
Adalimumab biosimilar (Prestige BioPharma)PBP-1502Phase ⅠPrestige BioPharma, HuonsArthritisDetails
Adalimumab biosimilar (Hetero Drugs)
Phase ⅢHetero DrugsRheumatoid arthritis (RA)Details
BB-2275BB-2275PreclinicalVernalisCachexia, AIDS related cachexia, Cancer related cachexiaDetails
Recombinant human TNF-α monoclonal antibody(SL Pharma/Combio)KM113IND FilingBeijing ShuangLu Pharmaceutical, CombioAutoimmune diseasesDetails
Genz-29155Genz-29155Phase ⅠSanofiTransplant rejection, Multiple sclerosis (MS)Details
DoramapimodBIBR-796; BIRB-0796; BIRB-796; BIRB-796-BS,BIBR796,BIRB0796,BIRB796 BSPhase ⅢBoehringer IngelheimPsoriasisDetails
Adalimumab biosimilar (Synermore Biologics)SYN-060IND FilingSynermore Biologics, Lonn Ryonn PharmaRheumatoid arthritis (RA)Details
OCS-02OCS-02Phase ⅡOculis Pharma, NovartisDry eye diseaseDetails
Adalimumab biosimilar (Eastern Biotech)JY-026,JY026Phase ⅠEastern BiotechJuvenile idiopathic arthritis (JIA), Plaque psoriasis, Ankylosing Spondylitis (AS), Crohn's disease, Rheumatoid arthritis (RA)Details
BCD-121BCD-121Phase ⅠBiocadRheumatoid arthritis (RA)Details
Golnerminogene pradenovecADgvEGR.TNF.11DPhase ⅢAsahi Kasei, GenVec, National Cancer InstitutePancreatic cancerDetails
Acetylcysteine/PentoxifyllinePTL-202Phase ⅠPacific Therapeutics, IntelGenx Corp, RA Chem PharmaIdiopathic pulmonary fibrosis (IPF)Details
FluorofenidoneAKF-PD,AKFPDPhase ⅠCentral South University, Dierepharma, Hainan Haiyao PharmaHepatic fibrosis, Renal fibrosisDetails
Wogonin
Phase ⅠDaewoong, China Pharmaceutical University, Hefei Cosource Medicine Technology, Buchang PharmaGastric cancer, Leukemia, Liver cancerDetails

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