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GUCY2C

Brief Information

Name:Heat-stable enterotoxin receptor
Target Synonym:EC 4.6.1,EC:4.6.1.2,GC-C,STAR,GUC2C,hSTAR,GUCY2C,Guanylate Cyclase 2C,STA Receptor,Guanylyl Cyclase C,Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor),Heat-Stable Enterotoxin Receptor,Heat Stable Enterotoxin Receptor,EC 4.6.1.2,DIAR6,MECIL,MUCIL,In
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Approved

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Part of Bioactivity data

GUC-HF2H8-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of anti-GUCY2C CAR-293 cells were stained with 100 μL of 1 μg/mL of FITC-Labeled Human GUCY2C, His Tag (Cat. No. GUC-HF2H8) and negative control protein respectively. FITC signal was used to evaluate the binding activity (QC tested).

GUC-H52H5-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of anti-GUCY2C CAR-293 cells were stained with 100 µL of 1 µg/mL Human GUCY2C, His Tag (Cat. No. GUC-H52H5) and negative control protein respectively, washed and then followed by PE anti-His antibody and analyzed with FACS (Routinely tested).

GUC-C5255-ELISA
Cynomolgus GUCY2C, Fc TagCynomolgus GUCY2C, Fc Tag (Cat. No. GUC-C5255) ELISA bioactivity

Immobilized Cynomolgus GUCY2C, Fc Tag (Cat. No. GUC-C5255) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human GUCY2C Antibody, Human IgG1 (Cat. No. GUC-M78) with a linear range of 0.1-3 ng/mL (QC tested).

GUC-H82E9-MALS-HPLC
Biotinylated Human GUCY2C, His,Avitag (Cat. No. ) MALS images

The purity of Biotinylated Human GUCY2C, His,Avitag (Cat. No. GUC-H82E9) was more than 90% and the molecular weight of this protein is around 70-85 kDa verified by SEC-MALS.

Bioactivity-ELISA
Biotinylated Human GUCY2C, His,AvitagBiotinylated Human GUCY2C, His,Avitag (Cat. No. GUC-H82E9) ELISA bioactivity

Immobilized Biotinylated Human GUCY2C, His,Avitag (Cat. No. GUC-H82E9) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate, can bind Monoclonal Anti-Human GUCY2C Antibody, Human IgG1 with a linear range of 0.2-2 ng/mL (QC tested).

Synonym Name

GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C

Background

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Plecanatide SP-304; GCRA Approved Synergy Pharmaceuticals Trulance United States Constipation; Chronic idiopathic constipation Salix Pharmaceuticals 2017-01-19 Constipation; Irritable Bowel Syndrome; Chronic idiopathic constipation Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Dolcanatide SP-333; WU-977T914K Phase 2 Clinical Synergy Pharmaceuticals Constipation Details

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