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Your Position: Home > GUCY2C

GUCY2C

GUCY2C Protein Product ListCompare or Buy

Product> Filter Results

Cat. No.	Species	Product Description
GUC-H82E9	Human	Biotinylated Human GUCY2C / Guanylyl cyclase C Protein, His,Avitag™
GUC-C5255	Cynomolgus	Cynomolgus GUCY2C / Guanylyl cyclase C Protein, Fc Tag
GUC-C52H6	Cynomolgus	Cynomolgus GUCY2C / Guanylyl cyclase C Protein, His Tag
GUC-M5254	Mouse	Mouse GUCY2C / Guanylyl cyclase C Protein, Fc Tag
GUC-M52H3	Mouse	Mouse GUCY2C / Guanylyl cyclase C Protein, His Tag
GUC-H82F8	Human	Biotinylated Human GUCY2C / Guanylyl cyclase C Protein, Fc,Avitag™
GUC-HF2H8	Human	FITC-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His Tag
GUC-H52H5	Human	Human GUCY2C / Guanylyl cyclase C Protein, His Tag
GUC-H5257	Human	Human GUCY2C / Guanylyl cyclase C Protein, Fc Tag

GUCY2C Part of Bioactivity data

GUC-HF2H8-Cell-based assay

FACS assay shows that recombinant Biotinylated FACS

2e5 of Anti-GUCY2C CAR-293 cells were stained with 100 μL of 1 μg/mL of FITC-Labeled Human GUCY2C, His Tag (Cat. No. GUC-HF2H8) and negative control protein respectively, FITC signal was used to evaluate the binding activity(QC tested).

Protocol

GUC-H52H5-Cell-based assay

2e5 of anti-GUCY2C CAR-293 cells were stained with 100 µL of 1 µg/mL Human GUCY2C, His Tag (Cat. No. GUC-H52H5) and negative control protein respectively, washed and then followed by PE anti-His antibody and analyzed with FACS (Routinely tested).

Protocol

GUC-C5255-ELISA

Immobilized Cynomolgus GUCY2C, Fc Tag (Cat. No. GUC-C5255) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human GUCY2C Antibody, Human IgG1 (Cat. No. GUC-M78) with a linear range of 0.1-3 ng/mL (QC tested).

Protocol

GUC-H82E9-ELISA

Immobilized Biotinylated Human GUCY2C, His,Avitag (Cat. No. GUC-H82E9) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate, can bind Monoclonal Anti-Human GUCY2C Antibody, Human IgG1 with a linear range of 0.2-2 ng/mL (QC tested).

Protocol

GUCY2C Molecule Synonym Name

GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C

GUCY2C Molecule Background

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.