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Your Position: Home > JAK1

JAK1

Brief Information

Name:Tyrosine-protein kinase JAK1
Target Synonym:JAK1B,Tyrosine-protein kinase JAK1,JAK1,Janus Kinase 1,JAK1A,EC 2.7.10.2,JAK-1,JTK3,EC:2.7.10.2,EC 2.7.10
Number of Launched Drugs:6
Number of Drugs in Clinical Trials:17
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
JA1-H5547 Human Human JAK1 Protein, His Tag
JA1-H5547-structure
JA1-H5547-sds

Synonym Name

JAK1,JAK-1,JAK1A,JAK1B,Jak1

Background

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (?c) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Peficitinib ASP-015K; JNJ-54781532 Approved Astellas Pharma Inc Smyraf Japan Arthritis, Rheumatoid Astellas Pharma Inc 2019-03-29 Arthritis, Rheumatoid Details
Upadacitinib ABT-494 Approved Abbvie Inc Rinvoq EU Colitis, Ulcerative Abbvie Inc 2019-08-16 Non-radiographic axial spondyloarthritis; Giant Cell Arteritis; Arthritis, Rheumatoid; Spondylarthritis; Spondylitis, Ankylosing; Arthritis, Juvenile; Takayasu Arteritis; Lupus Erythematosus, Systemic; Colitis, Ulcerative; Arthritis, Psoriatic; Hidradenitis Suppurativa; Crohn Disease; Dermatitis, Atopic; Vitiligo Details
Abrocitinib PF-4965842; PF-04965842 Approved Pfizer Inc 希必可, Cibinqo Mainland China Dermatitis, Atopic Pfizer Investment Co Ltd 2021-09-09 Pruritus; Kidney Diseases; Genetic Diseases, Inborn; Skin Diseases, Eczematous; Skin Diseases; Immune System Diseases; Dermatitis; Psoriasis; Food Hypersensitivity; Hepatic Insufficiency; Prurigo; Hypersensitivity, Immediate; Skin Diseases, Genetic; Dermatitis, Atopic; Eczema; Hypersensitivity Details
Baricitinib LY-3009104; INCB-028050 Approved Incyte Corp 艾乐明, Olumiant United States Alopecia Areata Eli Lilly And Company 2017-02-13 Polymyalgia Rheumatica; Vitiligo; Dermatitis, Atopic; Wounds and Injuries; Skin Diseases, Papulosquamous; Renal Insufficiency, Chronic; Skin Ulcer; Hepatic Insufficiency; Diabetic Nephropathies; Pyoderma; Coronavirus Infections; Severe Acute Respiratory Syndrome; Psoriasis; Lupus Erythematosus, Systemic; Liver Diseases; Purpura, Thrombocytopenic, Idiopathic; Skin Diseases; Arthritis, Juvenile; Lupus Nephritis; Pemphigoid, Benign Mucous Membrane; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid; Pyoderma Gangrenosum; Myositis; Alopecia Areata; Dermatomyositis; Liver Cirrhosis, Biliary; Infections; HIV Infections Details
Ruxolitinib Phosphate INCB-018424; INC-424; INCB-424; INCB-18424 Approved Incyte Corp Jakafi, Jakavi, OPZELURA United States Vitiligo Incyte Corp 2011-11-16 Lymphoma; Respiratory Distress Syndrome, Adult; Chronic eosinophilic leukemia (CEL); Thrombocytosis; Prostatic Neoplasms; Psoriasis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Carcinoma, Intraductal, Noninfiltrating; Coronavirus Infections; Primary Myelofibrosis; Hepatomegaly; Bone Marrow Diseases; Hyperplasia; Leukemia, Myeloid, Chronic-Phase; Carcinoma, Pancreatic Ductal; Dermatitis; Leukemia, Myeloid, Acute; Lymphohistiocytosis, Hemophagocytic; Cachexia; Lymphoma, Non-Hodgkin; Carcinoma, Squamous Cell; Hidradenitis Suppurativa; Splenomegaly; Thrombocythemia, Essential; Dermatitis, Atopic; Vitiligo; Carcinoma, Non-Small-Cell Lung; Precancerous Conditions; Eczema; Leukemia, Lymphocytic, Chronic, B-Cell; Alopecia Areata; Bone Marrow Neoplasms; Leukemia; Hematologic Diseases; Cytokine Release Syndrome; Preleukemia; Hematopoietic stem cell transplantation (HSCT); Hematologic Neoplasms; Bronchiolitis Obliterans; Leukemia, Myeloid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Hypereosinophilic Syndrome; Details
Filgotinib Maleate G-146034-101; GS-6034; G-146034; GLPG-0634 Approved Galapagos Nv Jyseleca Japan Colitis, Ulcerative Gilead Sciences Kk 2020-09-24 Non-radiographic axial spondyloarthritis; Inflammatory Bowel Diseases; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Kidney Diseases; Lupus Erythematosus, Cutaneous; Sjogren's Syndrome; Lupus Nephritis; Glomerulonephritis, Membranous; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease Details
Tofacitinib Citrate CP-690550-10; CKD-374; Tasocitinib; BI-764524; CP-690550; AC-1101; IMG 003; SSS-32 Approved Pfizer Inc Jakvinus, Xeljanz EU, United States Spondylitis, Ankylosing Pfizer Europe Ma Eeig, Pfizer Inc 2012-11-06 Uveitis; Arthritis, Juvenile; Dry Eye Syndromes; Polymyalgia Rheumatica; Psoriasis; Granuloma Annulare; Lupus Erythematosus, Systemic; Colitis, Ulcerative; Arthritis, Psoriatic; Hepatic Insufficiency; Sarcoidosis, Pulmonary; Spondylitis; Hamman-Rich Syndrome; Inflammation; Hidradenitis Suppurativa; Dermatitis, Atopic; Crohn Disease; Diabetic Retinopathy; Vitiligo; Eczema; Plaque psoriasis; Down Syndrome; Alopecia; Keratoconjunctivitis Sicca; Myositis; Lupus Erythematosus, Discoid; Alopecia Areata; Scleritis; Sacroiliitis; Depression; Dermatomyositis; Rejection of renal transplantation; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Glioblastoma; Lupus Erythematosus, Cutaneous; Sarcoidosis; Scleroderma, Systemic; Sjogren's Syndrome; Coronavirus Disease 2019 (COVID-19); Kidney Diseases Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
LBG-1600M Phase 1 Clinical Suzhou Longbotai Pharmaceutical Co Ltd Dermatitis, Atopic Details
TT-00420/Atezolizumab Phase 1 Clinical Gastrointestinal Neoplasms Details
NIP-046 NIP-046 Phase 1 Clinical National Institutes Of Pharmaceutical Research And Development Co Ltd Arthritis, Rheumatoid Details
WXFL-10203614 WXFL-10203614 Phase 2 Clinical Wuxi Fuxin Pharmaceutical Research And Development Co Ltd, Wuxi Apptec Co Ltd Arthritis, Rheumatoid Details
LNK-01001 LNK01001; LNK-01001 Phase 2 Clinical Lynk Pharmaceutical (Hangzhou) Co Ltd Spondylitis, Ankylosing; Arthritis, Rheumatoid; Dermatitis, Atopic Details
H-018 H018; H-018 Phase 1 Clinical Jiangsu Carephar Pharmaceutical Co Ltd, Nanjing Shenzhou Jiamei Pharmaceutical Co Ltd Arthritis, Rheumatoid Details
ATI-501 A-201; ATI-501; ATI-50001 Rigel Pharmaceuticals Inc Details
ATI-1777 Phase 2 Clinical Aclaris Therapeutics Inc Dermatitis, Atopic Details
Fingolimod/Tofacitinib FMX-114 Vyne Therapeutics Inc Details
MAX-40070 MAX-40070 Phase 1 Clinical Maxinovel Pty Ltd Alopecia Areata Details
ATI-502 A-301; ATI-502; ATI-50002 Rigel Pharmaceuticals Inc Details
INCB-47986 INCB-47986 INCB-047986 Incyte Corp Details
TLL-018 TLL-018 Phase 2 Clinical Tll Pharmaceutical Arthritis, Rheumatoid; Chronic Urticaria; Psoriasis; Urticaria Details
INCB-52793 INCB-52793; INCB-052793 Incyte Corp Details
Jaktinib hydrochloride Phase 3 Clinical Suzhou Zelgen Biosciences Co Ltd Polycythemia Vera; Alopecia Areata; Myelodysplastic Syndromes; Myeloproliferative Disorders; Spondylitis, Ankylosing; Idiopathic Pulmonary Fibrosis; Graft vs Host Disease; Psoriasis; Primary Myelofibrosis; Hepatic Insufficiency; Thrombocythemia, Essential; Dermatitis, Atopic Details
PF-6263276 PF-6263276; PF-06263276 Pfizer Pharmaceuticals Ltd (China) Details
VR-588 VR-588 Vectura Details
FZJ-003 FZJ-003 Phase 1 Clinical Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd Arthritis, Rheumatoid Details
AZD-1480 AZD-1480 Astrazeneca Pharmaceutical Co Ltd Details
INCB-054707 INCB-54707; INCB54707; INCB054707; INCB-054707 Incyte Corp Details
Elsubrutinib/Upadacitinib ABBV-599 Phase 1 Clinical Abbvie Inc Lupus Erythematosus, Systemic Details
Tinengotinib TT-00420 Phase 2 Clinical TransThera Sciences (Nanjing) Inc Solid tumours; Biliary Tract Neoplasms; Stomach Neoplasms; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Sarcoma; Cholangiocarcinoma; Prostatic Neoplasms; Breast Neoplasms; Thyroid Neoplasms; Gallbladder Neoplasms Details
Brepocitinib PF-06700841-15; PF-6700841; PF-841; PF-06700841 Phase 3 Clinical Pfizer Inc Alopecia; Alopecia Areata; Dermatomyositis; Lupus Erythematosus, Systemic; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Hidradenitis Suppurativa; Dermatitis, Atopic; Vitiligo; Crohn Disease Details
Itacitinib INCB-039110-adipate; INCB-39110; INCB-039110; IBI-377 Phase 3 Clinical Incyte Corp Lung Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Breast Neoplasms; Hemic and Lymphatic Diseases; Sarcoma; Colitis, Ulcerative; Primary Myelofibrosis; Asthma; Colorectal Neoplasms; Lymphohistiocytosis, Hemophagocytic; Lymphoma; Thrombocytosis; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Endometrial Neoplasms; Myelodysplastic-Myeloproliferative Diseases; Neoplasm Metastasis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Liposarcoma, Myxoid; Melanoma; Arthritis, Rheumatoid; Cytokine Release Syndrome; Lymphoma, B-Cell; Bronchiolitis Obliterans; Solid tumours; Head and Neck Neoplasms; Chondrosarcoma; Leiomyosarcoma; Polycythemia Vera; Pruritus; Carcinoma, Renal Cell; Hematologic Neoplasms; Graft vs Host Disease; Hodgkin Disease; Neoplasms; Carcinoma, Transitional Cell; Myelodysplastic Syndromes; Pancreatic Neoplasms; Liposarcoma; Sarcoma, Synovial; Psoriasis Details
LW-402 LW-402 Phase 1 Clinical Shanghai Longwood Biopharmaceuticals Co Ltd Arthritis, Rheumatoid Details
Golidocitinib AZD-4205; DZD-4205; NC-0322 Phase 2 Clinical Astrazeneca Plc, Dizal (Jiangsu) Pharmaceutical Co Ltd Lymphoma, T-Cell, Peripheral; Lymphoma, T-Cell, Cutaneous; Carcinoma, Non-Small-Cell Lung Details
GLPG-3121 GLPG-3121 Phase 1 Clinical Galapagos Nv Details
CS-12192 CS12192 Phase 1 Clinical Shenzhen Chipscreen Biosciences Co Ltd Enteritis; Alopecia Areata; Autoimmune Diseases; Graft vs Host Disease; Multiple Sclerosis; Lupus Erythematosus, Systemic; Dermatitis, Atopic Details
Deuterated Ruxolitinib CTP-543 Phase 3 Clinical Concert Alopecia Areata; Kidney Diseases; Hepatic Insufficiency; Primary Myelofibrosis; Leukemia, Lymphocytic, Chronic, B-Cell Details
Ivarmacitinib sulfate SHR-0302; ARQ-252 Phase 3 Clinical Jiangsu Hengrui Medicine Co Ltd Non-radiographic axial spondyloarthritis; Alopecia Areata; Spondylarthritis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Hepatic Insufficiency; Arthritis, Psoriatic; Eczema; Vitiligo; Dermatitis, Atopic; Crohn Disease Details
PG-011 PG-011 Phase 2 Clinical Prime Gene Therapeutics Co Ltd Epidermolysis Bullosa; Rhinitis, Allergic; Prurigo; Eye Diseases; Dermatitis, Atopic Details
WXSH-0150 WXSH-0150; TUL-01101 Phase 1 Clinical Zhuhai United Laboratories Co Ltd Arthritis, Rheumatoid Details
VC-005 VC-005 Phase 1 Clinical Jiangsu Weikeer Pharmaceutical Technology Co Ltd Inflammatory Bowel Diseases; Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Vitiligo Details
AQ-280 AQ-280 Phase 1 Clinical Aqilion AB Eosinophilic Esophagitis Details

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