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JAK1

Brief Information

Name:Tyrosine-protein kinase JAK1
Target Synonym:EC 2.7.10,EC:2.7.10.2,JAK1B,Tyrosine-protein kinase JAK1,JAK1,Janus Kinase 1,JAK1A,EC 2.7.10.2,JAK-1,JTK3
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:13
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
JA1-H5547 Human Human JAK1 Protein, His Tag
JA1-H5547-structure
JA1-H5547-sds

Synonym Name

JAK1,JAK-1,JAK1A,JAK1B,Jak1

Background

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (?c) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Baricitinib LY-3009104; INCB-028050 Approved Incyte Corp 艾乐明, Olumiant EU Dermatitis, Atopic Eli Lilly Nederland Bv 2017-02-13 Infections; Liver Cirrhosis, Biliary; Alopecia Areata; Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19); Arthritis, Juvenile; Skin Diseases; Liver Diseases; Lupus Erythematosus, Systemic; Psoriasis; Diabetic Nephropathies; Hepatic Insufficiency; Skin Diseases, Papulosquamous; Dermatitis, Atopic Details
Peficitinib ASP-015K; JNJ-54781532 Approved Astellas Pharma Inc Smyraf Japan Arthritis, Rheumatoid Astellas Pharma Inc 2019-03-29 Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative Details
Upadacitinib ABT-494 Approved Abbvie Inc Rinvoq EU Arthritis, Psoriatic; Spondylitis, Ankylosing Abbvie Deutschland Gmbh & Co Kg 2019-08-16 Giant Cell Arteritis; Arthritis, Rheumatoid; Spondylarthritis; Spondylitis, Ankylosing; Arthritis, Juvenile; Lupus Erythematosus, Systemic; Takayasu Arteritis; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Dermatitis, Atopic; Vitiligo; Crohn Disease Details
Ruxolitinib Phosphate INC-424; INCB-424; INCB-18424; INCB-018424 Approved Incyte Corp Jakafi, Jakavi United States Graft vs Host Disease Incyte Corp 2011-11-16 Arthritis, Rheumatoid; Thrombocythemia, Essential; Vitiligo; Dermatitis, Atopic; Leukemia, Myeloid, Acute; Primary Myelofibrosis; Psoriasis; Thrombocytosis; Prostatic Neoplasms; Coronavirus Disease 2019 (COVID-19); Myeloproliferative Disorders; Solid tumours; beta-Thalassemia; Myelodysplastic Syndromes; Graft vs Host Disease; Anemia; Polycythemia Vera; Alopecia Areata; Leukemia; Bone Marrow Neoplasms; Cytokine Release Syndrome Details
Filgotinib Maleate G-146034-101; GS-6034; G-146034; GLPG-0634 Approved Galapagos Nv Jyseleca Japan Arthritis, Rheumatoid Gilead Sciences Inc 2020-09-24 Inflammatory Bowel Diseases; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Sjogren's Syndrome; Kidney Diseases; Lupus Erythematosus, Cutaneous; Glomerulonephritis, Membranous; Lupus Nephritis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Upadacitinib/ABBV-105 ABBV-599 Phase 2 Clinical Abbvie Inc Arthritis, Rheumatoid; Lupus Erythematosus, Systemic Details
ATI-501 A-201; ATI-501; ATI-50001 Phase 2 Clinical Rigel Pharmaceuticals Inc Alopecia Details
ATI-1777 Phase 2 Clinical Aclaris Therapeutics Inc Dermatitis, Atopic Details
WXFL10203614 WXFL-10203614; WXFL10203614 Phase 2 Clinical Wuxi Apptec Co Ltd, Wuxi Fuxin Pharmaceutical Research And Development Co Ltd Arthritis, Rheumatoid Details
CS-12192 CS12192 Phase 1 Clinical Shenzhen Chipscreen Biosciences Co Ltd Enteritis; Alopecia Areata; Autoimmune Diseases; Arthritis, Rheumatoid; Graft vs Host Disease; Multiple Sclerosis; Lupus Erythematosus, Systemic; Dermatitis, Atopic Details
ATI-502 A-301; ATI-502; ATI-50002 Phase 2 Clinical Rigel Pharmaceuticals Inc Alopecia; Alopecia Areata; Dermatitis, Atopic Details
Brepocitinib PF-841; PF-6700841; PF-06700841; PF-06700841-15 Phase 2 Clinical Pfizer Inc Alopecia; Alopecia Areata; Kidney Diseases; Lupus Erythematosus, Systemic; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Hidradenitis Suppurativa; Vitiligo; Crohn Disease; Dermatitis, Atopic Details
Momelotinib Dihydrochloride CYT-387; GS-0387 Phase 3 Clinical Gilead Sciences Inc Polycythemia; Polycythemia Vera; Pancreatic Intraductal Neoplasms; Primary Myelofibrosis; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Thrombocythemia, Essential Details
AZD-4205 NC-0322; AZD-4205; DZD-4205 Phase 2 Clinical Astrazeneca Plc, Dizal (Jiangsu) Pharmaceutical Co Ltd Lymphoma, T-Cell, Peripheral; Inflammatory Bowel Diseases; Autoimmune Diseases; Carcinoma, Non-Small-Cell Lung Details
VC-005 VC-005 Details
LBG-1600M Phase 1 Clinical Suzhou Longbotai Pharmaceutical Co Ltd Dermatitis, Atopic Details
WXSH-0150 WXSH-0150 Phase 1 Clinical Zhuhai United Laboratories Co Ltd Arthritis, Rheumatoid Details
Itacitinib INCB-039110-adipate; INCB-39110; INCB-039110; IBI-377 Phase 3 Clinical Incyte Corp Carcinoma, Transitional Cell; Melanoma; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Lymphoma; Endometrial Neoplasms; Lung Neoplasms; Colitis, Ulcerative; Colorectal Neoplasms; Primary Myelofibrosis; Psoriasis; Breast Neoplasms; Thrombocytosis; Head and Neck Neoplasms; Hodgkin Disease; Neoplasms; Graft vs Host Disease; Arthritis, Rheumatoid; Pancreatic Neoplasms; Carcinoma, Renal Cell; Polycythemia Vera; Solid tumours; Bronchiolitis Obliterans; Lymphoma, B-Cell; Cytokine Release Syndrome; Hematologic Neoplasms Details
Jaktinib hydrochloride Phase 3 Clinical Suzhou Zelgen Biosciences Co Ltd Alopecia Areata; Polycythemia Vera; Spondylitis, Ankylosing; Idiopathic Pulmonary Fibrosis; Myeloproliferative Disorders; Myelodysplastic Syndromes; Graft vs Host Disease; Psoriasis; Primary Myelofibrosis; Hepatic Insufficiency; Dermatitis, Atopic; Thrombocythemia, Essential; Plaque psoriasis Details
SHR-0302 SHR-0302 Phase 3 Clinical Jiangsu Hengrui Medicine Co Ltd Alopecia Areata; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Colitis, Ulcerative; Hepatic Insufficiency; Arthritis, Psoriatic; Crohn Disease; Vitiligo; Dermatitis, Atopic Details
INCB-054707 INCB-54707; INCB54707; INCB054707; INCB-054707 Phase 2 Clinical Incyte Corp Hidradenitis Suppurativa; Vitiligo Details
Deuterated Ruxolitinib CTP-543 Phase 3 Clinical Concert Alopecia; Alopecia Areata; Primary Myelofibrosis Details
ARQ-252 ARQ-252 Phase 2 Clinical Arcutis Vitiligo; Eczema Details

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