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JAK1

Brief Information

Name:Tyrosine-protein kinase JAK1
Target Synonym:JAK1B,Tyrosine-protein kinase JAK1,JAK1,Janus Kinase 1,JAK1A,EC 2.7.10.2,JAK-1,JTK3,EC:2.7.10.2,EC 2.7.10
Number of Launched Drugs:10
Number of Drugs in Clinical Trials:41
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
JA1-H5547 Human Human JAK1 Protein, His Tag
JA1-H5547-structure
JA1-H5547-sds
ACRO Quality

Synonym Name

JAK1,JAK-1,JAK1A,JAK1B,Jak1

Background

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (?c) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body

Clinical and Translational Updates

Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Filgotinib Maleate G-146034-101; GS-6034; G-146034; GLPG-0634 Approved Galapagos Nv Jyseleca EU Arthritis, Rheumatoid Galapagos Nv 2020-09-24 Lupus Erythematosus, Cutaneous; Crohn Disease; Behcet Syndrome; Uveitis; Colitis, Ulcerative; Arthritis, Psoriatic; Arthritis, Juvenile; Lupus Nephritis; Glomerulonephritis, Membranous; Non-radiographic axial spondyloarthritis; Spondylitis, Ankylosing; Sjogren's Syndrome; Arthritis, Rheumatoid; Inflammatory Bowel Diseases; Immunoglobulin G4-Related Disease; Myositis; Renal Insufficiency Details
Deuterated Ruxolitinib CTP-543; C-21543 phosphate; CTP-543 phosphate Approved Concert LEQSELVI United States Alopecia Areata Sun Pharmaceutical Industries Ltd 2024-07-25 Alopecia Areata; Renal Insufficiency; Hepatic Insufficiency Details
Peficitinib ASP-015K; JNJ-54781532 Approved Astellas Pharma Inc Smyraf Japan Arthritis, Rheumatoid Astellas Pharma Inc 2019-03-29 Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative Details
Momelotinib Dihydrochloride CYT-387; GS-0387; GSK-3070785 Approved Gilead Sciences Inc, Cytopia Pty Ltd Ojjaara, Omjjara United States Primary Myelofibrosis; Anemia Glaxosmithkline Llc, Glaxosmithkline Plc 2023-09-15 Polycythemia Vera; Anemia; Neoplasms; Myeloproliferative Disorders; Pancreatic Intraductal Neoplasms; Primary Myelofibrosis; Carcinoma, Pancreatic Ductal; Splenomegaly; Thrombocythemia, Essential; Carcinoma, Non-Small-Cell Lung Details
Abrocitinib PF-4965842; PF-04965842 Approved Pfizer Inc Cibinqo, CIBINQO, 希必可 United Kingdom Dermatitis, Atopic Pfizer Inc 2021-09-09 Food Hypersensitivity; Plaque psoriasis; Hypersensitivity; Dermatitis, Atopic; Eczema; Skin Diseases, Genetic; Hypersensitivity, Immediate; Hepatic Insufficiency; Prurigo; Post-Acute COVID-19 Syndrome; Granuloma Annulare; Pruritus; Prurigo Nodularis; Immune System Diseases; Genetic Diseases, Inborn; Skin Diseases; Skin Diseases, Eczematous; Dermatitis; Fatigue; Sarcoidosis; Renal Insufficiency Details
Tofacitinib Citrate CP-690550; AC-1101; IMG 003; CGB-500; CP-690550-10; CKD-374; Tasocitinib; BI-764524 Approved Pfizer Inc Jakvinus, Xeljanz, 尚杰 United States Arthritis, Rheumatoid Pf Prism Cv 2012-11-06 Inflammation; Arthritis, Juvenile; Lung Diseases, Interstitial; Dermatitis; Psoriasis; Lupus Erythematosus, Systemic; Granuloma Annulare; Colitis, Ulcerative; Arthritis, Psoriatic; Sarcoidosis, Pulmonary; Hepatic Insufficiency; Granulomatous Disease, Chronic; Dry Eye Syndromes; Lymphoma, T-Cell, Cutaneous; Uveitis; Hidradenitis Suppurativa; Crohn Disease; Kidney Failure, Chronic; Plaque psoriasis; Dermatitis, Atopic; Amyotrophic Lateral Sclerosis; Eczema; Vitiligo; Lupus Erythematosus, Discoid; Keratoconjunctivitis Sicca; Alopecia; Non-radiographic axial spondyloarthritis; Alopecia Areata; Pneumonia; Gastrointestinal Diseases; Renal Insufficiency; Depression; Scleritis; Down Syndrome; Dermatomyositis; Rejection of renal transplantation; Sacroiliitis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Sjogren's Syndrome; Coronavirus Disease 2019 (COVID-19); Glioblastoma; Scleroderma, Systemic; Sarcoidosis; Lupus Erythematosus, Cutaneous; Spondylitis Details
Golidocitinib DZD-4205; AZD-4205; NC-0322 Approved Astrazeneca Plc, Dizal (Jiangsu) Pharmaceutical Co Ltd 高瑞哲 Mainland China Lymphoma, T-Cell, Peripheral Dizal (Jiangsu) Pharmaceutical Co Ltd 2024-06-18 Lymphoma, T-Cell, Peripheral; Lymphoma, T-Cell, Cutaneous; Carcinoma, Non-Small-Cell Lung Details
Upadacitinib ABT-494 Approved Abbott Laboratories RINVOQ LQ, 瑞福, Rinvoq, Rinvoq Lq United States Arthritis, Rheumatoid Abbvie Inc 2019-08-16 Lung Diseases, Interstitial; Vitiligo; Dermatitis, Atopic; Crohn Disease; Hidradenitis Suppurativa; Arthritis, Psoriatic; Colitis, Ulcerative; Takayasu Arteritis; Lupus Erythematosus, Systemic; Blepharitis; Non-radiographic axial spondyloarthritis; Arthritis, Juvenile; Sleep Wake Disorders; Spondylitis, Ankylosing; Spondylarthritis; Arthritis, Rheumatoid; Polyarticular Juvenile Idiopathic Arthritis; Giant Cell Arteritis; Alopecia Areata Details
Baricitinib LY-3009104; INCB-028050 Approved Incyte Corp 艾乐明, Olumiant EU Arthritis, Rheumatoid Eli Lilly Nederland BV 2017-02-13 Diabetic Nephropathies; Pyoderma; Post-Acute COVID-19 Syndrome; Severe Acute Respiratory Syndrome; Lupus Erythematosus, Systemic; Psoriasis; Cholangitis, Sclerosing; Coronavirus Infections; Anhedonia; Skin Ulcer; Polymyalgia Rheumatica; Hepatic Insufficiency; Wounds and Injuries; Aicardi Goutieres syndrome; Renal Insufficiency, Chronic; Skin Diseases, Papulosquamous; Lichen Planus, Oral; Acute Lung Injury; Dermatitis, Atopic; Vitiligo; Coronavirus Disease 2019 (COVID-19); HIV Infections; Diabetes Mellitus, Type 1; Pyoderma Gangrenosum; Alopecia Areata; Cerebral Hemorrhage; Dermatomyositis; Myositis; Nephritis; Depression; Infections; Arthritis, Rheumatoid; Pemphigoid, Benign Mucous Membrane; Graft vs Host Disease; Conjunctivitis; Arthritis, Juvenile; Skin Diseases; Liver Diseases; Lupus Nephritis Details
Ruxolitinib Phosphate INC-424; INCB-424; INCB-18424; RUX; INCB 018424 phosphate; INCB-018424 Approved Incyte Corp OPZELURA, Jakavi, Jakafi United States Primary Myelofibrosis Incyte Corp 2011-11-16 Pancytopenia; Lymphoma; Hyperplasia; Leukemia, Myeloid, Chronic-Phase; Lichen Planus; Prurigo; Hepatomegaly; Primary Myelofibrosis; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Leukemia, Myeloid, Acute; Coronavirus Infections; Anemia, Aplastic; Prostatic Neoplasms; Thrombocytosis; Carcinoma, Intraductal, Noninfiltrating; Ectodermal Dysplasia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Breast Neoplasms; Vitiligo; Exanthema; Leukemia, T-Cell; Eczema; Leukemia, Lymphocytic, Chronic, B-Cell; Dermatitis, Atopic; Myelodysplastic-Myeloproliferative Diseases; Carcinoma, Non-Small-Cell Lung; Thrombocythemia, Essential; Psoriasis; Lymphohistiocytosis, Hemophagocytic; Lichen Sclerosus et Atrophicus; Hidradenitis Suppurativa; Carcinoma, Squamous Cell; Cachexia; Lymphoma, Non-Hodgkin; Splenomegaly; Polycythemia Vera; Pancreatic Neoplasms; Myelodysplastic Syndromes; Arthritis, Rheumatoid; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Alopecia Areata; Squamous Cell Carcinoma of Head and Neck; L Details

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
PG-011 PG-011 Phase 3 Clinical Prime Gene Therapeutics Co Ltd Radiodermatitis; Epidermolysis Bullosa; Dermatitis; Rhinitis, Allergic; Prurigo; Eye Diseases; Dermatitis, Atopic; Vitiligo Details
Povorcitinib INCB-54707; INCB54707; INCB054707; INCB-054707 Phase 3 Clinical Incyte Corp Pruritus; Renal Insufficiency; Chronic Urticaria; Kidney Diseases; Prurigo Nodularis; Urticaria; Asthma; Hidradenitis Suppurativa; Angioedema; Vitiligo Details
Brepocitinib PF-06700841-15; PF-6700841; PF-841; PF-06700841 Phase 3 Clinical Pfizer Inc Colitis, Ulcerative; Crohn Disease; Vitiligo; Dermatitis, Atopic; Plaque psoriasis; Panuveitis; Hidradenitis Suppurativa; Uveitis; Uveitis, Posterior; Alopecia; Arthritis, Psoriatic; Psoriasis; Lupus Erythematosus, Systemic; Alopecia Areata; Renal Insufficiency; Uveitis, Intermediate; Dermatomyositis Details
WXFL-10203614 WXFL-10203614; [14C]WXFL10203614 Phase 3 Clinical Wuxi Fuxin Pharmaceutical Research And Development Co Ltd, Wuxi Apptec Co Ltd Arthritis, Rheumatoid; Colitis, Ulcerative; Dermatitis, Atopic; Crohn Disease Details
TLL-018 TLL-018 Phase 3 Clinical Tll Pharmaceutical Llc Arthritis, Rheumatoid; Chronic Urticaria; Lupus Erythematosus, Systemic; Psoriasis; Colitis, Ulcerative; Urticaria; Plaque psoriasis; Dermatitis, Atopic Details
Tinengotinib TT-00420; TT 00420; TT00420 Phase 3 Clinical TransThera Sciences (Nanjing) Inc Biliary Tract Neoplasms; Solid tumours; Carcinoma, Renal Cell; Stomach Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Transitional Cell; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Cholangiocarcinoma; Sarcoma; Prostatic Neoplasms; Gallbladder Neoplasms; Thyroid Neoplasms Details
LW-402 [14C]LW402; LW-402 Phase 3 Clinical Shanghai Longwood Biopharmaceuticals Co Ltd Inflammatory Bowel Diseases; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Dermatitis, Atopic; Vitiligo Details
VC-005 VC-005 Phase 3 Clinical Jiangsu Vcare Pharmatech Co Ltd Inflammatory Bowel Diseases; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Joint Diseases; Colitis, Ulcerative; Dermatitis, Atopic; Eczema; Crohn Disease; Vitiligo Details
ICP-332 ICP-332 Phase 3 Clinical InnoCare Pharma Ltd Psoriasis; Vitiligo; Dermatitis, Atopic Details
LNK-01001 LNK-01001; LNK01001; LNK-001; LNK001; LNK-207; EQ-121 Phase 3 Clinical Lynk Pharmaceutical (Hangzhou) Co Ltd Spondylitis, Ankylosing; Arthritis, Rheumatoid; Dermatitis, Atopic Details
Itacitinib INCB-039110-adipate; INCB-39110; INCB-039110; IBI-377 Phase 3 Clinical Incyte Corp Leukemia, Myeloid, Acute; Multiple Myeloma; Sarcoma; Hemic and Lymphatic Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thrombocytosis; Breast Neoplasms; Leukemia, B-Cell; Primary Myelofibrosis; Colitis, Ulcerative; Asthma; Colorectal Neoplasms; Lymphoma; Liposarcoma; Lymphoma, Non-Hodgkin; Lung Neoplasms; Endometrial Neoplasms; Lymphohistiocytosis, Hemophagocytic; Leukemia, Prolymphocytic, T-Cell; Carcinoma, Hepatocellular; Liposarcoma, Myxoid; Plaque psoriasis; Neoplasm Metastasis; Melanoma; Carcinoma, Non-Small-Cell Lung; Myelodysplastic-Myeloproliferative Diseases; Graft vs Host Disease; Leiomyosarcoma; Lymphoma, B-Cell; Chondrosarcoma; Bronchiolitis Obliterans; Solid tumours; Cytokine Release Syndrome; Head and Neck Neoplasms; Leukemia, Myelogenous, Chronic; Leukemia; Polycythemia Vera; Carcinoma, Renal Cell; Pruritus; Hematologic Neoplasms; Hodgkin Disease; Myelodysplastic Syndromes; Neoplasms; Lymphoma, Large B-Cell, Diffuse; Arthritis, Rheumatoid; Pancreatic Neoplasms; Myeloproliferative Di Details
WXSH-0150 WXSH-0150; TUL-01101 Phase 2 Clinical Zhuhai United Laboratories Co Ltd Arthritis, Rheumatoid; Dermatitis, Atopic Details
Elsubrutinib/Upadacitinib ABBV-599 Phase 2 Clinical Abbvie Inc Arthritis, Rheumatoid; Lupus Erythematosus, Systemic Details
NS-229 NS-229 Phase 2 Clinical Neurosearch As Eosinophilic Granulomatosis With Polyangiitis; Epilepsy Details
TDM-180935 TDM-180935 Phase 2 Clinical Jiaxing TechnoDerma Medicines Inc Dermatitis, Atopic Details
AC-201 AC-201 Phase 2 Clinical Accro Bioscience (Suzhou) Co Ltd Psoriasis; Lupus Erythematosus, Systemic; Uveitis Details
VVN-461 VVN461e; VVN-461-e; VVN-461 Phase 2 Clinical VivaVision Biotech Inc Uveitis, Anterior; Uveitis; Inflammation; Postoperative inflammation Details
Fingolimod/Tofacitinib FMX-114 Phase 2 Clinical Vyne Therapeutics Inc Dermatitis, Atopic Details
QY201 QY-201; QY201 Phase 2 Clinical E-nitiate Biopharmaceuticals (Hangzhou) Co Ltd Alopecia Areata; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Prurigo; Dermatitis, Atopic Details
AZD-4604 AZD-4604 Phase 2 Clinical Astrazeneca Plc Asthma Details
Lepzacitinib Phase 2 Clinical Aclaris Therapeutics Inc Dermatitis, Atopic Details
CS-12192 CS12192 Phase 1 Clinical Shenzhen Chipscreen Biosciences Co Ltd Enteritis; Alopecia Areata; Autoimmune Diseases; Graft vs Host Disease; Multiple Sclerosis; Lupus Erythematosus, Systemic; Dermatitis, Atopic Details
FZJ-003 FZJ-003 Phase 1 Clinical Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co Ltd Arthritis, Rheumatoid; Dermatitis, Atopic Details
Frevecitinib VR-588; KN-002; KN-002 (Kinaset Therapeutics/Vectura) Phase 1 Clinical Vectura Ltd Asthma; Pulmonary Disease, Chronic Obstructive Details
GLPG-3121 GLPG-3121 Phase 1 Clinical Galapagos Nv Details
tofacitinib (3S Bio) SSS-32 Phase 1 Clinical 3sbio Inc Arthritis, Rheumatoid Details
LP-0184 LP-0184 Phase 1 Clinical Leo Pharma A/S Dermatitis, Atopic Details
Tofacitinib(Biora Therapeutics) BT-600; PGN-600 Phase 1 Clinical Progenity Inc Colitis, Ulcerative Details
Ruxolitinib (Taro Pharmaceuticals) Phase 1 Clinical Taro Pharmaceuticals Usa Inc Dermatitis, Atopic Details
Tofacitinib citrate (TWi Biotechnology) AC-1101; IMG 003 Phase 1 Clinical Twi Biotechnology Inc Granuloma Annulare Details
GDC-0214 RG-6151; GDC-0214 Phase 1 Clinical Genentech Inc Asthma Details
BHV-8000 TLL-041; TLL041 Phase 1 Clinical Hangzhou Highlightll Pharmaceutical Co Ltd Alzheimer Disease; Parkinson Disease; Central Nervous System Diseases; Amyotrophic Lateral Sclerosis Details
QY-211 QY211; QY-211 Phase 1 Clinical E-nitiate Biopharmaceuticals (Hangzhou) Co Ltd Psoriasis; Dermatitis, Atopic; Eczema; Vitiligo Details
AQ-280 AQ-280 Phase 1 Clinical Aqilion AB Eosinophilic Esophagitis Details
PG-018 PG-018 Phase 1 Clinical Prime Gene Therapeutics Co Ltd Nephrosis; Glomerulonephritis, Membranous Details
MAX-40070 MAX-40070 Phase 1 Clinical Maxinovel Pty Ltd Alopecia Areata Details
H-018 H018; H-018 Phase 1 Clinical Jiangsu Carephar Pharmaceutical Co Ltd, Nanjing Shenzhou Jiamei Pharmaceutical Co Ltd Arthritis, Rheumatoid; Dermatitis, Atopic; Vitiligo Details
TT-00420/Atezolizumab Phase 1 Clinical TransThera Sciences (Nanjing) Inc Gastrointestinal Neoplasms Details
LBG-1600M Phase 1 Clinical Suzhou Longbotai Pharmaceutical Co Ltd Dermatitis, Atopic Details
LNK-01002 LNK01002 Phase 1 Clinical Lynk Pharmaceutical (Hangzhou) Co Ltd Hematologic Neoplasms; Polycythemia Vera; Myeloproliferative Disorders; Primary Myelofibrosis; Leukemia, Myeloid, Acute; Thrombocythemia, Essential Details
NIP-046 NIP-046 Phase 1 Clinical National Institutes Of Pharmaceutical Research And Development Co Ltd Arthritis, Rheumatoid; Chronic Urticaria Details
Tofacitinib controlled release (Triastek) T-21; T21 Clinical Triastek Inc Colitis, Ulcerative Details

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