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JAK1 Molecule Information

Name:Tyrosine-protein kinase JAK1
Target Synonym:EC 2.7.10,EC:,JAK1B,Tyrosine-protein kinase JAK1,JAK1,Janus Kinase 1,JAK1A,EC,JAK-1,JTK3
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:13
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
JA1-H5547 Human Human JAK1 Protein, His Tag

JAK1 Molecule Synonym Name


JAK1 Molecule Background

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (?c) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body

JAK1 References

JAK1 Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Upadacitinib ABT-494 Approved Abbvie Inc Rinvoq EU Arthritis, Psoriatic; Spondylitis, Ankylosing s:31:"Abbvie Deutschland Gmbh & Co Kg"; 2019-08-16 Giant Cell Arteritis; Spondylarthritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Lupus Erythematosus, Systemic; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Dermatitis, Atopic; Crohn Disease Details
Baricitinib LY-3009104; INCB-028050 Approved Incyte Corp 艾乐明, Olumiant EU Dermatitis, Atopic s:22:"Eli Lilly Nederland Bv"; 2017-02-13 Infections; Liver Cirrhosis, Biliary; Alopecia Areata; Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19); Arthritis, Juvenile; Skin Diseases; Liver Diseases; Lupus Erythematosus, Systemic; Psoriasis; Diabetic Nephropathies; Hepatic Insufficiency; Skin Diseases, Papulosquamous; Dermatitis, Atopic Details
Ruxolitinib Phosphate INC-424; INCB-424; INCB-18424; INCB-018424 Approved Incyte Corp Jakafi, Jakavi United States Graft vs Host Disease s:11:"Incyte Corp"; 2011-11-16 Myeloproliferative Disorders; Thrombocythemia, Essential; Vitiligo; Dermatitis, Atopic; Leukemia, Myeloid, Acute; Primary Myelofibrosis; Psoriasis; Thrombocytosis; Prostatic Neoplasms; Coronavirus Disease 2019 (COVID-19); Solid tumours; Arthritis, Rheumatoid; beta-Thalassemia; Graft vs Host Disease; Myelodysplastic Syndromes; Anemia; Alopecia Areata; Polycythemia Vera; Leukemia; Bone Marrow Neoplasms Details
Peficitinib ASP-015K; JNJ-54781532 Approved Astellas Pharma Inc Smyraf Japan Arthritis, Rheumatoid s:19:"Astellas Pharma Inc"; 2019-03-29 Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative Details
Filgotinib Maleate G-146034-101; GS-6034; G-146034; GLPG-0634 Approved Galapagos Nv Jyseleca Japan Arthritis, Rheumatoid s:19:"Gilead Sciences Inc"; 2020-09-24 Inflammatory Bowel Diseases; Lupus Erythematosus, Cutaneous; Arthritis, Rheumatoid; Sjogren's Syndrome; Spondylitis, Ankylosing; Kidney Diseases; Glomerulonephritis, Membranous; Lupus Nephritis; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Crohn Disease Details

JAK1 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Upadacitinib/ABBV-105 ABBV-599 Phase 2 Clinical Abbvie Inc Arthritis, Rheumatoid; Lupus Erythematosus, Systemic Details
AZD-4205 NC-0322; AZD-4205; DZD-4205 Phase 2 Clinical Astrazeneca Plc, Dizal (Jiangsu) Pharmaceutical Co Ltd Lymphoma, T-Cell, Peripheral; Inflammatory Bowel Diseases; Autoimmune Diseases; Carcinoma, Non-Small-Cell Lung Details
ATI-502 A-301; ATI-502; ATI-50002 Phase 2 Clinical Rigel Pharmaceuticals Inc Alopecia; Alopecia Areata; Dermatitis, Atopic Details
ATI-501 A-201; ATI-501; ATI-50001 Phase 2 Clinical Rigel Pharmaceuticals Inc Alopecia Details
ATI-1777 Phase 2 Clinical Aclaris Therapeutics Inc Dermatitis, Atopic Details
INCB-054707 INCB-54707; INCB54707; INCB054707; INCB-054707 Phase 2 Clinical Incyte Corp Hidradenitis Suppurativa Details
CS-12192 CS12192 Phase 1 Clinical Shenzhen Chipscreen Biosciences Co Ltd Enteritis; Alopecia Areata; Arthritis, Rheumatoid; Graft vs Host Disease; Autoimmune Diseases; Multiple Sclerosis; Lupus Erythematosus, Systemic; Dermatitis, Atopic Details
WXFL10203614 WXFL-10203614; WXFL10203614 Phase 2 Clinical Wuxi Apptec Co Ltd, Wuxi Fuxin Pharmaceutical Research And Development Co Ltd Arthritis, Rheumatoid Details
SHR-0302 SHR-0302 Phase 3 Clinical Jiangsu Hengrui Medicine Co Ltd Alopecia Areata; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Colitis, Ulcerative; Hepatic Insufficiency; Crohn Disease; Dermatitis, Atopic; Vitiligo Details
Brepocitinib PF-841; PF-6700841; PF-06700841; PF-06700841-15 Phase 2 Clinical Pfizer Inc Alopecia; Alopecia Areata; Kidney Diseases; Lupus Erythematosus, Systemic; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Hidradenitis Suppurativa; Dermatitis, Atopic; Vitiligo; Crohn Disease Details
Deuterated Ruxolitinib CTP-543 Phase 3 Clinical Concert Alopecia; Alopecia Areata; Primary Myelofibrosis Details
Momelotinib Dihydrochloride CYT-387; GS-0387 Phase 3 Clinical Gilead Sciences Inc Polycythemia; Polycythemia Vera; Pancreatic Intraductal Neoplasms; Primary Myelofibrosis; Carcinoma, Pancreatic Ductal; Carcinoma, Non-Small-Cell Lung; Thrombocythemia, Essential Details
ARQ-252 ARQ-252 Phase 2 Clinical Arcutis Eczema; Vitiligo Details
Itacitinib IBI-377; INCB-39110; INCB-039110; INCB-039110-adipate Phase 3 Clinical Incyte Corp Pancreatic Neoplasms; Melanoma; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Lymphoma; Endometrial Neoplasms; Lung Neoplasms; Colorectal Neoplasms; Colitis, Ulcerative; Primary Myelofibrosis; Thrombocytosis; Breast Neoplasms; Psoriasis; Lymphoma, B-Cell; Carcinoma, Transitional Cell; Hodgkin Disease; Neoplasms; Arthritis, Rheumatoid; Graft vs Host Disease; Polycythemia Vera; Carcinoma, Renal Cell; Bronchiolitis Obliterans; Hematologic Neoplasms; Cytokine Release Syndrome; Head and Neck Neoplasms; Solid tumours Details
Jaktinib hydrochloride Phase 3 Clinical Suzhou Zelgen Biosciences Co Ltd Polycythemia Vera; Alopecia Areata; Idiopathic Pulmonary Fibrosis; Spondylitis, Ankylosing; Psoriasis; Primary Myelofibrosis; Thrombocythemia, Essential; Dermatitis, Atopic; Plaque psoriasis Details

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