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RNA-dependent RNA polymerase

RNA-dependent RNA polymerase Molecule Information

Name:RNA-directed RNA polymerase
Target Synonym:RNA Replicase
Number of Launched Drugs:2
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Approved

RNA-dependent RNA polymerase Molecule Synonym Name

RdRp,RNA-dependent RNA polymerase,NSP12,nsp12,Pol,COVID-19

RNA-dependent RNA polymerase Molecule Background

Viral RNA-dependent RNA polymerases (RdRPs) are a class of nucleic acid polymerases bearing unique features from global architecture to catalytic mechanisms. RNA-dependent RNA polymerase involved in post-transcriptional gene silencing (PTGS). Possesses ssRNA and ssDNA-dependent polymerase activity, but does not have priming activity. In recent years, numerous viral RdRP crystal structures have improved the understanding of these molecular machines, in particular, for how they carry out each nucleotide addition cycle (NAC) as directed by the RNA template.

RNA-dependent RNA polymerase References

RNA-dependent RNA polymerase Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Favipiravir T-705; T-705a Approved Taisho Toyama, Toyama Chemical Co Ltd Avigan Mainland China Influenza, Human s:36:"Zhejiang Hisun Pharmaceutical Co Ltd"; 2014-03-24 Coronavirus Disease 2019 (COVID-19); Influenza A virus infections; Influenza, Human; Hepatic Insufficiency Details
Remdesivir GS-5734 Approved Gilead Sciences Inc Veklury, Captisol, ベクルリー United States Coronavirus Disease 2019 (COVID-19) s:19:"Gilead Sciences Inc"; 2020-05-07 Respiratory Tract Infections; Coronavirus Disease 2019 (COVID-19); Nerve Degeneration; Severe Acute Respiratory Syndrome; Coronavirus Infections Details

RNA-dependent RNA polymerase Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Galidesivir BCX-4430 Phase 1 Clinical Biocryst Pharmaceuticals Hemorrhagic Fever, Ebola; Marburg Virus Disease; Zika Virus Infection; Yellow Fever; Coronavirus Disease 2019 (COVID-19); Filoviridae Infections; Coronavirus Infections Details
PC-786 PC-786 Phase 2 Clinical Pulmocide Respiratory Syncytial Virus Infections Details
AL-794 AL-794; JNJ-5806; JNJ-64155806 Phase 1 Clinical Janssen Global Services Llc, Johnson & Johnson Influenza, Human Details
ZSP1273 ZSP-1273; ZSYM-005 Phase 3 Clinical Guangdong Zhongsheng Pharmaceutical Co Ltd, Wuxi Apptec Co Ltd Influenza A virus infections; Influenza, Human Details

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