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Cat. No. Species Product Description Structure Purity Feature
CHEK-ATP101 Human HEK293/Human TMPRSS2-HA-P2A-mGFP Stable Cell Line
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Part of Bioactivity data

CHEK-ATP101-Cell-based assay

Expression analysis of human TMPRSS2 on HEK293/Human TMPRSS2-HA-P2A-mGFP Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human TMPRSS2-HA-P2A-mGFP Stable Cell Line or negative control cell.
Recombinant Anti-TMPRSS2 antibody was used as the primary antibody.
Goat Anti-Rabbit IgG H&L (Alexa Fluor® 647) was used as the secondary antibody.

Synonym Name

TMPRSS2,PRSS10,Serine protease 10


Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV).

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