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FAP

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FAP Part of Bioactivity data

FAP-HF263-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of Anti-FAP CAR-293 cells were stained with 100 μL of 1 μg/mL FITC-Labeled Human FAP, Fc Tag (Cat. No. FAP-HF263) and negative control protein respectively, FITC signal was used to evaluate the binding activity (QC tested).

FAP-H5263-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of Anti-FAP CAR-293 cells were stained with 100 μL of 1 μg/mL of Human FAP Protein, Fc Tag (Cat. No. FAP-H5263) and negative control protein respectively, washed and then followed by PE anti-human IgG Fc antibody and analyzed with FACS (Routinely tested).

FAP-HF243-ELISA
FITC-Labeled Human FAP Protein, His TagFITC-Labeled Human FAP Protein, His Tag (Cat. No. FAP-HF243) ELISA bioactivity

Immobilized Anti-FAP (Sibrotuzumab) Antibody,Human IgG1 at 1 μg/mL (100 μL/well) can bind FITC-Labeled Human FAP Protein, His Tag (Cat. No. FAP-HF243) with a linear range of 0.078-0.625 μg/mL (QC tested).

FAP-HF243-MALS-HPLC
FITC-Labeled Human FAP Protein, His Tag (Cat. No. ) MALS images

The purity of FITC-Labeled Human FAP Protein, His Tag (Cat. No.FAP-HF243) was more than 90% and the molecular weight of this protein is around 190-205 kDa verified by SEC-MALS.

Bioactivity-ELISA
FITC-Labeled Human FAP Protein, His TagFITC-Labeled Human FAP Protein, His Tag (Cat. No. FAP-HF243) ELISA bioactivity

Immobilized Anti-FAP (Sibrotuzumab) Antibody,Human IgG1 at 1 μg/mL (100 μL/well) can bind FITC-Labeled Human FAP Protein, His Tag (Cat. No. FAP-HF243) with a linear range of 0.078-0.625 μg/mL (QC tested).

FAP Molecule Synonym Name

FAP,FAPalpha,SIMP,Seprase,APCE

FAP Molecule Background

FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.

FAP References

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