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FAP

Brief Information

Name:Fibroblast activation protein alpha
Target Synonym:EC:,3.4.14.5,EC:3.4.21.26,EC:3.4.21.-,EC:3.4.14.5,EC:,3.4.21.-,170 kDa melanoma membrane-bound gelatinase,Seprase,Dipeptidyl peptidase FAP,APCE,Integral membrane serine protease,FAP,Post-Proline Cleaving Enzyme,FAPalpha,SIMP,Fibroblast Activation Protein,
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

FAP-HF263-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of anti-FAP CAR-293 cells were stained with 100 μL of 3 μg/mL of FITC-Labeled Human FAP, Fc Tag (Cat. No. FAP-HF263) and negative control protein respectively, FITC signal was used to evaluate the binding activity (QC tested).

FAP-HF243-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of anti-FAP CAR 293 cells were stained with 100 μL of 3 μg/mL of FITC-Labeled Human FAP, His Tag (Cat. No. FAP-HF243) and negative control protein respectively, FITC signals was used to evaluate the binding activity (QC tested).

FAP-M52H3-ELISA
Mouse FAP, His TagMouse FAP, His Tag (Cat. No. FAP-M52H3) ELISA bioactivity

Immobilized Mouse FAP, His Tag (Cat. No. FAP-M52H3) at 1 μg/mL (100 μL/well) can bind Anti-FAP Antibody, Mouse IgG2a (FAP5) with a linear range of 0.1-3 ng/mL (QC tested).

FAP-C52H3-MALS-HPLC
Cynomolgus FAP, His Tag (Cat. No. ) MALS images

The purity of Cynomolgus FAP, His Tag (Cat. No. FAP-C52H3) was more than 90% and the molecular weight of this protein is around 166-203 kDa verified by SEC-MALS.

Bioactivity-ELISA
Cynomolgus FAP, His TagCynomolgus FAP, His Tag (Cat. No. FAP-C52H3) ELISA bioactivity

Immobilized Cynomolgus FAP, His Tag (Cat. No. FAP-C52H3) at 1 μg/mL (100 μL/well) can bind Anti-FAP Antibody, Mouse IgG2a (FAP5) with a linear range of 1-63 ng/mL (QC tested).

Synonym Name

FAP,FAPalpha,SIMP,Seprase,APCE

Background

FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Nectin4/FAP-targeted CAR-T cell therapy (The Sixth Affiliated Hospital of Wenzhou Medical University) Phase 1 Clinical Wenzhou Medical University Neoplasms Details
Talabostat (BioXcel) PT-100; BXCL-701 Phase 2 Clinical Inveni Pancreatic Neoplasms; Prostatic Neoplasms Details
RG-7461 RG-7461; FAP-IL2v; aFAP-IL2v; RO-6874281; FAP-IL2v FP Phase 2 Clinical F. Hoffmann-La Roche Ltd Head and Neck Neoplasms; Solid tumours; Carcinoma, Renal Cell; Esophageal Neoplasms; Breast Neoplasms; Uterine Cervical Neoplasms; Melanoma Details
Talabostat PT-100 Phase 2 Clinical Midatech Pharma Plc Skin Neoplasms; Pancreatic Neoplasms; Neuroendocrine Tumors; Prostatic Neoplasms; Carcinoma, Small Cell; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Adenocarcinoma; Leukemia, Lymphocytic, Chronic, B-Cell; Melanoma Details
RO-7300490 RO-7300490; RG-6189 Phase 1 Clinical F. Hoffmann-La Roche Ltd Solid tumours Details
3B-201 FAP-2286; 3B-201 Phase 2 Clinical 3b Pharmaceuticals Solid tumours Details

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