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FAP

FAP Molecule Information

Name:Fibroblast activation protein alpha
Target Synonym:EC:?3.4.14.5?EC:3.4.21.26?EC:3.4.21.-?EC:3.4.14.5?EC:?3.4.21.-?170 kDa melanoma membrane-bound gelatinase?Seprase?Dipeptidyl peptidase FAP?APCE?Integral membrane serine protease?FAP?Post-Proline Cleaving Enzyme?FAPalpha?SIMP?Fibroblast Activation Protein?
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:4
Lastest Research Phase:Phase 2 Clinical

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FAP Part of Bioactivity data

FAP-HF263-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of Anti-FAP CAR-293 cells were stained with 100 μL of 1 μg/mL FITC-Labeled Human FAP, Fc Tag (Cat. No. FAP-HF263) and negative control protein respectively, FITC signal was used to evaluate the binding activity (QC tested).

FAP-HF243-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of anti-FAP CAR 293 cells were stained with 100 μL of 3 μg/mL of FITC-Labeled Human FAP, His Tag (Cat. No. FAP-HF243) and negative control protein respectively, FITC signals was used to evaluate the binding activity (QC tested).

FAP-HF263-ELISA
FITC-Labeled Human FAP Protein, Fc TagFITC-Labeled Human FAP Protein, Fc Tag (Cat. No. FAP-HF263) ELISA bioactivity

Immobilized Monoclonal Anti-FAP (FAP5) Antibody, Mouse IgG2a (Cat. No. ) at 1 μg/mL (100 μL/well) can bind FITC-Labeled Human FAP Protein, Fc Tag (Cat. No. FAP-HF263) with a linear range of 0.039-0.625 μg/mL (QC tested).

FAP-M82Q5-MALS-HPLC
Biotinylated Mouse FAP, His,Avitag™ (Cat. No. ) MALS images

The purity of Biotinylated Mouse FAP, His,Avitag™ (Cat. No. FAP-M82Q5) was more than 90% and the molecular weight of this protein is around 190-200 kDa verified by SEC-MALS."

Bioactivity-ELISA
Biotinylated Mouse FAP, His,Avitag™Biotinylated Mouse FAP, His,Avitag™ (Cat. No. FAP-M82Q5) ELISA bioactivity

Immobilized Biotinylated Mouse FAP, His,Avitag (Cat. No. FAP-M82Q5) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate. can bind Monoclonal Anti-FAP (FAP5) Antibody, Mouse IgG2a with a linear range of 0.3-2 ng/mL (QC tested).

FAP Molecule Synonym Name

FAP,FAPalpha,SIMP,Seprase,APCE

FAP Molecule Background

FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.

FAP References

FAP Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
RG-7461 RG-7461; FAP-IL2v; aFAP-IL2v; RO-6874281; FAP-IL2v FP Phase 1 Clinical F. Hoffmann-La Roche Ltd Head and Neck Neoplasms; Carcinoma, Renal Cell; Breast Neoplasms; Melanoma Details
Nectin4/FAP-targeted CAR-T cell therapy (The Sixth Affiliated Hospital of Wenzhou Medical University) Phase 1 Clinical Wenzhou Medical University Neoplasms Details
Talabostat (BioXcel) PT-100; BXCL-701 Phase 2 Clinical Inveni Pancreatic Neoplasms; Prostatic Neoplasms Details
Talabostat PT-100 Phase 2 Clinical Midatech Pharma Plc Pancreatic Neoplasms; Skin Neoplasms; Neuroendocrine Tumors; Prostatic Neoplasms; Lung Neoplasms; Carcinoma, Small Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Melanoma; Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis Details

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