Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > FAP


Brief Information

Name:Fibroblast activation protein alpha
Target Synonym:EC:3.4.21.-,EC:,EC:,3.4.21.-,EC:,170 kDa melanoma membrane-bound gelatinase,Seprase,Dipeptidyl peptidase FAP,APCE,Integral membrane serine protease,FAP,Post-Proline Cleaving Enzyme,Gelatine degradation protease FAP,Fibroblast activation protein alpha,Surface-expressed protease,FAPalpha,SIMP,Fibroblast Activation Protein, Alpha,Serine Integral Membrane Protease,Prolyl Endopeptidase FAP,EC,EC,EC 3.4.21.-,DPPIV,FAPA,EC:,
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:12
Lastest Research Phase:Phase 2 Clinical

Product ListCompare or Buy

ACRO Quality

Part of Bioactivity data

FAP-HP245-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

5e5 of anti-FAP CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human FAP, His Tag (Cat. No. FAP-HP245) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

FAP-HF263-Cell-based assay

2e5 of anti-FAP CAR-293 cells were stained with 100 μL of 3 μg/mL of FITC-Labeled Human FAP, Fc Tag (Cat. No. FAP-HF263) and negative control protein respectively, FITC signal was used to evaluate the binding activity (QC tested).


Anti-FAP Antibody, Mouse IgG2a (FAP5) captured on CM5 chip via anti-mouse antibodies surface can bind Rat FAP, His Tag (Cat. No. FAP-R5246) with an affinity constant of 0.839 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).


Anti-FAP Antibody, Mouse IgG2a (FAP5) captured on CM5 chip via anti-mouse antibodies surface can bind Cynomolgus FAP, His Tag (Cat. No. FAP-C52H3) with an affinity constant of 3.10 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Synonym Name



FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
177Lu-PNT6555(Point Biopharma) PNT-6555 Phase 1 Clinical Point Biopharma Inc Solid tumours; Esophageal Neoplasms; Sarcoma; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Melanoma Details
68Ga-FAPI-RGD 68Ga-FAPI-RGD Phase 1 Clinical Peking Union Medical College Hospital Lung Neoplasms Details
177Lu-FAP-2286 177Lu-FAP-2286 Phase 2 Clinical 3B Pharmaceuticals GmbH Solid tumours Details
MP-0317 MP-0317 Phase 1 Clinical Molecular Partners Ag Solid tumours; Neoplasms Details
Nectin4/FAP-targeted CAR-T cell therapy (The Sixth Affiliated Hospital of Wenzhou Medical University) Phase 1 Clinical Wenzhou Medical University, The Sixth Affiliated Hospital Of Wenzhou Medical University Solid tumours Details
OMTX-705 OMTX-705 Phase 1 Clinical Oncomatryx Biopharma Sl Solid tumours Details
[18F]FAPI-74 FAPI-74; [18F]FAPI-74 Phase 2 Clinical Sofie Biliary Tract Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Carcinoma, Pancreatic Ductal; Gastrointestinal Neoplasms; Carcinoma, Hepatocellular Details
RO-7300490 RO-7300490; RG-6189 Phase 1 Clinical F. Hoffmann-La Roche Ltd Solid tumours; Neoplasms Details
68Ga-FAP-2286 68Ga-FAP-2286; 68-Ga-FAP-2286 Phase 2 Clinical 3B Pharmaceuticals GmbH Solid tumours; Neoplasm Metastasis Details
68Ga-FAPI-46 Phase 2 Clinical Karolinska University Hospital Adenomatous Polyposis Coli; Idiopathic Interstitial Pneumonias; Radiation Pneumonitis; Pneumonia; Stomach Neoplasms; Pancreatic Neoplasms; Carcinoma, Ovarian Epithelial; Lung Diseases, Interstitial; Pulmonary Fibrosis; Bile Duct Neoplasms; Carcinoma, Pancreatic Ductal; Alveolitis, Extrinsic Allergic; Pneumoconiosis Details
Talabostat PT-100; BXCL-701 Phase 2 Clinical Midatech Pharma Plc, Bioxcel Therapeutics Inc Neuroblastoma; Melanoma; Leukemia, Lymphocytic, Chronic, B-Cell; Adenocarcinoma; Neoplasms, Germ Cell and Embryonal; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Lung Neoplasms; Carcinoma, Pancreatic Ductal; Leukemia, Myeloid, Acute; Carcinoma, Small Cell; Brain Neoplasms; Solid tumours; Sarcoma; Prostatic Neoplasms; Central Nervous System Neoplasms; Neuroendocrine Tumors; Skin Neoplasms; Myelodysplastic Syndromes; Pancreatic Neoplasms; Kidney Neoplasms; Ovarian Neoplasms; Liver Neoplasms Details
MP-0310 MP-0310; AMG-506 Phase 1 Clinical Molecular Partners Ag, Amgen Inc Solid tumours Details
177Lu-LNC1004 177Lu-LNC1004; 177Lu-LNC-1004 Phase 1 Clinical Shanghai Lannacheng Biotechnology Co Ltd Solid tumours Details
Simlukafusp alfa FAP-IL2v; RG-7461; aFAP-IL2v; RO-6874281; FAP-IL2v FP Phase 2 Clinical F. Hoffmann-La Roche Ltd Head and Neck Neoplasms; Solid tumours; Carcinoma, Renal Cell; Esophageal Neoplasms; Breast Neoplasms; Uterine Cervical Neoplasms; Melanoma Details

This web search service is supported by Google Inc.

Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
+1 888-377-6111
1 Innovation Way, Newark, DE 19711, USA

Leave a message