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ILDR2 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
IL2-H5259 Human Human ILDR2 Protein, Fc Tag
IL2-H52H7 Human Human ILDR2 Protein, His Tag
IL2-M52H5 Mouse Mouse ILDR2 Protein, His Tag

ILDR2 Molecule Synonym Name


ILDR2 Molecule Background

ILDR2 belongs to the immunoglobulin superfamily. May be involved in lipid homeostasis and ER stress pathways. ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.

ILDR2 References

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