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ILDR2

ILDR2 Protein Product ListCompare or Buy

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Cat. No. Species Product Description Structure Purity Feature
IL2-H5259 Human Human ILDR2 Protein, Fc Tag
IL2-H5259-structure
IL2-H5259-sds
IL2-H52H7 Human Human ILDR2 Protein, His Tag
IL2-H52H7-structure
IL2-M52H5 Mouse Mouse ILDR2 Protein, His Tag
IL2-M52H5-structure

ILDR2 Molecule Synonym Name

ILDR2,C1orf32

ILDR2 Molecule Background

ILDR2 belongs to the immunoglobulin superfamily. May be involved in lipid homeostasis and ER stress pathways. ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.

ILDR2 References

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