ILDR2
ILDR2 Molecule Information
Name:Immunoglobulin-like domain-containing receptor 2
Target Synonym:Immunoglobulin-like domain-containing receptor 2?ILDR2?C1orf32?Immunoglobulin-Like Domain Containing Receptor 2?LISCH-Like?DJ782G3.1?Immunoglobulin Like Domain Containing Receptor 2?Chromosome 1 Open Reading Frame 32
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical
ILDR2 Molecule Synonym Name
ILDR2,C1orf32
ILDR2 Molecule Background
ILDR2 belongs to the immunoglobulin superfamily. May be involved in lipid homeostasis and ER stress pathways. ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.
ILDR2 References
ILDR2 Clinical Drug Information
Name |
Research Code |
Research Phase |
Company |
Indications |
Clinical Trials |
BAY-1905254 |
BAY-1905254 |
Phase 1 Clinical |
Compugen |
Neoplasms |
Details
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