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Your Position: Home > ILDR2

ILDR2

Brief Information

Name:Immunoglobulin-like domain-containing receptor 2
Target Synonym:Immunoglobulin-like domain-containing receptor 2,ILDR2,C1orf32,Immunoglobulin-Like Domain Containing Receptor 2,LISCH-Like,DJ782G3.1,Immunoglobulin Like Domain Containing Receptor 2,Chromosome 1 Open Reading Frame 32
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
IL2-H5259 Human Human ILDR2 Protein, Fc Tag
IL2-H5259-structure
IL2-H5259-sds
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Synonym Name

ILDR2,C1orf32

Background

ILDR2 belongs to the immunoglobulin superfamily. May be involved in lipid homeostasis and ER stress pathways. ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Bapotulimab BAY-1905254 Phase 1 Clinical Compugen Ltd Solid tumours; Squamous Cell Carcinoma of Head and Neck Details

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