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Netrin receptor DCC

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Cat. No. Species Product Description Structure Purity Feature
NEC-H5254 Human Human Netrin receptor DCC / DCC Protein, Fc Tag (MALS verified)
NEC-H5254-structure
NEC-H5254-sds
NEC-H52H3 Human Human Netrin receptor DCC / DCC Protein, His Tag (MALS verified)
NEC-H52H3-structure
NEC-H52H3-sds
NEC-H52H3-elisa_2

Part of Bioactivity data

NEC-H52H3-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human Netrin-1 Protein immobilized on CM5 Chip can bind Human Netrin receptor DCC, His Tag (Cat. No. NEC-H52H3) with an affinity constant of 31.8 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

NEC-H5254-MALS-HPLC
Human Netrin receptor DCC, Fc Tag (Cat. No. ) MALS images

The purity of Human Netrin receptor DCC, Fc Tag(Cat. No. NEC-H5254) was more than 85% and the molecular weight of this protein is around 280-310 kDa verified by SEC-MALS.

  • Background
    Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

Synonym Name

Netrin receptor DCC,DCC,IGDCC1,netrin receptor DCC

Background

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

Clinical and Translational Updates

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