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Your Position: Home > IL-17 RA & IL-17 RC

IL-17 RA & IL-17 RC

Brief Information

Name:Interleukin-17 receptor A
Target Synonym:CDw217,IL-17 receptor A,IL17R,IL17RA,Interleukin 17 Receptor A,IL-17RA,Interleukin 17 Receptor,CD217 Antigen,HIL-17R,CANDF5,CD217,IMD51,Interleukin-17 receptor A
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
ILC-H5257 Human Human IL-17 RA&IL-17 RC Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)
ILC-H5257-structure
ILC-H5257-sds
ACRO Quality

Part of Bioactivity data

ILC-H5257-SPR
IL-17 RA & IL-17 RC SPR

Human IL17RA&IL17RC Protein, Fc Tag&Fc Tag (Cat. No. ILC-H5257) captured on CM5 chip via anti-human IgG Fc antibody can bind Human IL-17A&IL-17F Heterodimer Protein, Twin Strep&His Tag (Cat. No. ILF-H52W6) with an affinity constant of 50.8 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
ILC-H5257-BLI
IL-17 RA & IL-17 RC BLI

Loaded Human IL17RA&IL17RC Protein, Fc Tag&Fc Tag (Cat. No. ILC-H5257) on Protein A Biosensor, can bind Human IL17A, Tag Free with an affinity constant of 0.13 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Protocol

IL-17 RA & IL-17 RC Molecule Synonym Name

IL-17 RA & IL-17 RC,IL-17RA & IL-17RC,CD217 & IL-17 RC

IL-17 RA & IL-17 RC Molecule Background

IL17RA and IL17RC can form heterodimers and bind to the homodimers of IL17A and IL17F, and can also bind to the heterodimers formed by IL17A and IL17F.

IL-17 RA & IL-17 RC References

    Public Drug Information

    Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
    Brodalumab IL-17R mAb; MEDI-6365; KHK-4827; AMG-827 Approved Amgen Inc Siliq, Lumicef, Kyntheum, 立美芙 Mainland China Plaque psoriasis Kyowa Kirin 2016-07-04 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Scleroderma, Systemic; Psoriasis; Asthma; Arthritis, Psoriatic; Hidradenitis Suppurativa; Crohn Disease; Plaque psoriasis Details
    Brodalumab IL-17R mAb; MEDI-6365; KHK-4827; AMG-827 Approved Amgen Inc Siliq, Lumicef, Kyntheum, 立美芙 Mainland China Plaque psoriasis Kyowa Kirin 2016-07-04 Arthritis, Rheumatoid; Spondylitis, Ankylosing; Scleroderma, Systemic; Psoriasis; Asthma; Arthritis, Psoriatic; Hidradenitis Suppurativa; Crohn Disease; Plaque psoriasis Details

    Clinical Drug Information

    Name Research Code Research Phase Company Indications Clinical Trials
    LY-3114062 LY3114062; LY-3114062 Eli Lilly And Company Details
    XCUR-17 XCUR-17 Phase 1 Clinical Exicure Inc Psoriasis Details
    LY-3114062 LY3114062; LY-3114062 Eli Lilly And Company Details
    XCUR-17 XCUR-17 Phase 1 Clinical Exicure Inc Psoriasis Details

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