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SIRP alphaV2

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Part of Bioactivity data

SI2-H52H9-ELISA
Human SIRP alphaV2 Protein, His TagHuman SIRP alphaV2 Protein, His Tag (Cat. No. SI2-H52H9) ELISA bioactivity

Immobilized Human CD47, Fc Tag (HPLC-verified) (Cat. No. CD7-H5256) at 2 μg/mL (100 μL/well) can bind Human SIRP alphaV2 Protein, His Tag (Cat. No. SI2-H52H9) with a linear range of 0.078-1.25 μg/mL (QC tested).

SI2-H5257-MALS-HPLC
Human SIRP alphaV2 (31-148), Llama IgG2b Fc Tag (Cat. No. ) MALS images

The purity of Human SIRP alphaV2 (31-148), Llama IgG2b Fc Tag (Cat. No. SI2-H5257) is more than 90% and the molecular weight of this protein is around 75-95 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human SIRP alphaV2 (31-148), Llama IgG2b Fc TagHuman SIRP alphaV2 (31-148), Llama IgG2b Fc Tag (Cat. No. SI2-H5257) ELISA bioactivity

Immobilized Human SIRP alphaV2 (31-148), Llama IgG2b Fc Tag (Cat. No. SI2-H5257) at 5 μg/mL (100 μL/well) can bind Human CD47, His Tag (Cat. No. CD7-H5227) with a linear range of 0.02-0.313 μg/mL (QC tested).

Synonym Name

SHPS1,SIRPA,CD172A,BIT,MFR,MYD1,P84,PTPNS1

Background

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Clinical and Translational Updates

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