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LGR5

Brief Information

Name:Leucine-rich repeat-containing G-protein coupled receptor 5
Target Synonym:G Protein-Coupled Receptor 49,GRP49,HG38,FEX,G-protein coupled receptor HG38,GPR49,GPR67,G-protein coupled receptor 49,Leucine-rich repeat-containing G-protein coupled receptor 5,LGR5,Leucine Rich Repeat Containing G Protein-Coupled Receptor 5,G-Protein C
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
LG5-H52H3 Human Human LGR5 / GPR49 protein, His Tag
LG5-H52H3-structure
LG5-H52H3-sds
LG5-H52H3-elisa_1
LG5-H52H3-elisa_2

Part of Bioactivity data

LG5-H52H3-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human R-Spondin 3 immobilized on CM5 Chip can bind Human LGR5, His Tag (Cat. No. LG5-H52H3) with an affinity constant of 9.52 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

LG5-H52H3-ELISA
Human LGR5, His TagHuman LGR5, His Tag (Cat. No. LG5-H52H3) ELISA bioactivity

Immobilized Human R‑Spondin 3 at 2 μg/mL (100 μL/well) can bind Human LGR5, His Tag (Cat. No. LG5-H52H3) with a linear range of 5-39 ng/mL (QC tested).

Synonym Name

LGR5, GPR49, GPR67, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, Leucine-rich repeat-containing G-protein coupled receptor 5

Background

LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs. LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt/β-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
MCLA-158 MCLA-158 Phase 1 Clinical Merus Colorectal Neoplasms Details

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